Home > Name List By 7 > 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3, 4-dihydro-1H-quinolin-2-one China

CAS No 129722-12-9 , 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,
4-dihydro-1H-quinolin-2-one Search by region : China

  • Name: 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,
    4-dihydro-1H-quinolin-2-one
  • Synonyms: 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,
    4-dihydro-1H-quinolin-2-one;Abilify; OPC 31; Abilify Discmelt; 129722-12-9; aripiprazol; Opc 14597; Abilitat; OPC-14597; Discmelt;
  • CAS Registry Number:
  • Density: 1.263 g/cm3
  • Refractive index: 1.593
  • EINECS: 448.39
  • Molecular Weight: 448.38538
  • InchiKey: CEUORZQYGODEFX-UHFFFAOYSA-N
  • InChI: InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-
    1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,
    26,29)
  • Molecular Formula: C23H27Cl2N3O2
  • Molecular Structure:CAS No:129722-12-9 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,<br />4-dihydro-1H-quinolin-2-one

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References of 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,
4-dihydro-1H-quinolin-2-one
Title: Aripiprazole
CAS Registry Number: 129722-12-9
CAS Name: 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
Synonyms: 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril
Manufacturers' Codes: OPC-14597; OPC-31
Trademarks: Abilify (BMS); Abilitat (BMS)
Molecular Formula: C23H27Cl2N3O2
Molecular Weight: 448.39
Percent Composition: C 61.61%, H 6.07%, Cl 15.81%, N 9.37%, O 7.14%
Literature References: Dopamine-serotonin system stabilizer. Exhibits partial agonist activity at dopamine D2-receptors and serotonin 5-HT1A-receptors and antagonist activity at 5-HT2A-receptors. Prepn: Y. Oshiro et al., EP 367141; eidem, US 5006528 (1990, 1991 both to Otsuka); and pharmacology: Y. Oshiro et al., J. Med. Chem. 41, 658 (1998). Description of action on dopamine receptors: S. M. Stahl, J. Clin. Psychiatry 62, 841, 923 (2001); on serotonin receptors: S. Jordan et al., Eur. J. Pharmacol. 441, 137 (2002). Clinical trial in schizophrenia: J. M. Kane et al., J. Clin. Psychiatry 63, 763 (2002). Review of pharmacology: J. K. McGavin, K. L. Goa, CNS Drugs 16, 779-786 (2002); and clinical experience: P. E. Keck Jr., S. L. McElroy, Expert Opin. Invest. Drugs 12, 655-662 (2003).
Properties: Colorless, flake crystals from ethanol, mp 139.0-139.5°.
Melting point: mp 139.0-139.5°
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Dopamine-Serotonin System Stabilizer.