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CAS No 129580-63-8 , acetic acid

  • Name: acetic acid
  • Synonyms: YHI-601; AKOS015914237;azane; BMS-182751; FT-0601550; Satraplatin (USAN/INN);acetic acid; JM-216;dichloroplatinum; D05807; BMY-45594;cyclohexanamine;129580-63-8;
  • CAS Registry Number:
  • Flash Point: 32.2 ºC
  • Boiling Point: 134.5 ºCat 760 mmHg
  • Density: g/cm3
  • Flash Point: 32.2 ºC
  • Molecular Weight: 502.29856
  • InchiKey: TWEQNPPRXJRHHM-UHFFFAOYSA-L
  • InChI: InChI=1S/C6H13N.2C2H4O2.2ClH.H3N.Pt/c7-6-4-2-1-3-5-6;2*1-2(3)4;;;;/h6H,
    1-5,7H2;2*1H3,(H,3,4);2*1H;1H3;/q;;;;;;+2/p-2
  • Molecular Formula: C10H24Cl2N2O4Pt
  • Molecular Structure:CAS No:129580-63-8 acetic acid

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129580-63-8 (OC-6-43)-BIS(ACETATO-0)AMMINE-DICHLORO(CYCLOHEXANAMINE)PLATINUM (IV)

  • United States Colonial Metals Inc. [Manufacturer]
  • Tel: 410-398-7200
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    Elkton MD, 21922-0726 null,nullUnited States
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References of acetic acid
Title: Satraplatin
CAS Registry Number: 129580-63-8
CAS Name: (OC-6-43)-Bis(acetato-kO)amminedichloro(cyclohexanamine)-platinum
Synonyms: bis-acetato-ammine-dichloro-cyclohexylamine-platinum(IV)
Manufacturers' Codes: BMS-182751; BMY-45594; JM-216
Molecular Formula: C10H22Cl2N2O4Pt
Molecular Weight: 500.28
Percent Composition: C 24.01%, H 4.43%, Cl 14.17%, N 5.60%, O 12.79%, Pt 38.99%
Literature References: Orally active analog of cisplatin, q.v. Prepn: M. J. Abrams et al., EP 328274; eidem, US 5072011 (1989, 1991 both to Johnson Matthey). Clinical pharmacokinetics: S. Vouillamoz-Lorenz et al., Anticancer Res. 23, 2757 (2003). Clinical evaluation in small-cell lung cancer: E. Fokkema et al., J. Clin. Oncol. 17, 3822 (1999); in hormone-refractory prostate cancer: C. N. Sternberg et al., Oncology 68, 2 (2005). Review of clinical development: L. R. Kelland, Expert Opin. Invest. Drugs 9, 1373-1382 (2000).
Properties: Soly (mg/ml): water ~0.3; saline 0.4; 1-octanol 0.7. Partition coefficient (octanol/water): 0.1. LD50 in mice (mg/kg): 30 i.p.; 330 orally (Kelland).
Log P: Partition coefficient (octanol/water): 0.1
Toxicity data: LD50 in mice (mg/kg): 30 i.p.; 330 orally (Kelland)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Platinum Complexes.