CAS No 127000-20-8 , Gadobenate Dimeglumine

Name: Gadobenate Dimeglumine
Synonyms: Gadobenate Dimeglumine;GADOBENATE DIMEGLUMINE;
CAS Registry Number:127000-20-8
Molecular Weight: 0
InChI: InChI=1/C22H31N3O11.2C7H17NO5.Gd/c26-18(27)10-23(6-7-24(11-19(28)29)12-20(30)31)8-9-25(13-21(32)33)17(22(34)35)15-36-14-16-4-2-1-3-5-16;2*1-8-2-4(10)6(12)7(13)5(11)3-9;/h1-5,17H,6-15H2,(H,26,27)(H,28,29)(H,30,31)(H,32,33)(H,34,35);2*4-13H,2-3H2,1H3;/q;;;+3/p-3/t;2*4-,5+,6+,7+;/m.00./s1
Molecular Formula: C22H28GdN3O11
Molecular Structure:

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127000-20-8 2-[2-[2-(bis(carboxylatomethyl)amino)ethyl-(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]-3-phenylmethoxy-propanoate; gadolinium(+3) cation; hydrogen(+1) cation

Taizhou Belucky Co., Ltd [Manufacturer, Distributor/Wholesaler]
Tel: 86-576-88580899
Fax: +86-576-8889 5956
Address: null Taizhou,ZhejiangChina

127000-20-8 GADOBENATE DIMEGLUMINE

Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
Fax: +86 25 8345-3275
Address: Rm.902 Longyin Plaza,
No. 217 Zhongshan Rd.
(N)Nanjing 210009,China null,nullChina

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References of Gadobenate Dimeglumine

Title: Gadobenate Dimeglumine
CAS Registry Number: 127000-20-8
CAS Name: 1-Deoxy-1-(methylamino)-D-glucitol [4-(carboxy-kO)-5,8,11-tris[(carboxy-kO)methyl]-1-phenyl-2-oxa-5,8,11-triazatridecan-13-oato(5-)-kN5,kN8,kN11,kO13]gadolinate(2-) (2:1)
Synonyms: gadolinium benzyloxypropionictetraacetate dimeglumine; Gd-BOPTA/Dimeg
Manufacturers' Codes: B-19036/7
Trademarks: MultiHance (Bracco)
Molecular Formula: C36H62GdN5O21
Molecular Weight: 1058.15
Percent Composition: C 40.86%, H 5.91%, Gd 14.86%, N 6.62%, O 31.75%
Literature References: Intravascular paramagnetic MRI contrast agent. Prepn: E. Felder et al., EP 230893; eidem, US 4916246 (1987, 1990 both to Bracco); F. Ungerri et al., Inorg. Chem. 34, 633 (1995). HPLC determn in biological samples: T. Arbughi et al., J. Chromatogr. B 713, 415 (1998). Physicochemical properties: C. de Haen et al., J. Comput. Assist. Tomogr. 23, Suppl. 1, S161 (1999). Pharmacology: P. Tirone et al., ibid. S195. Pharmacokinetics: V. Lorusso et al., ibid. S181. Toxicology: A. Morisetti et al., ibid. S207. Clinical study in MRI of liver lesions: J. Petersein et al. Radiology 215, 727 (2000). Review of clinical studies: B. Hamm et al., J. Comput. Assist. Tomogr. 23, Suppl. 1, S53-S60 (1999).
Properties: Hygroscopic powder. mp 124°. Freely sol in water, sol in methanol. Practically insol in n-butanol, n-octanol, chloroform. Abs max 257.8 nm (e 203). [a]36520 -26.9° (c = 1.45 in water). Prepd as 0.5M soln, osmolality (37°) 1.97 mol/kg. d20 1.22. Viscosity (mPa.s): 9.2 (20°), 5.3 (37°). LD50 i.v. in mice (mmol/kg): 5.7 (at 1 mL/min), 7.9 (at 0.2 mL/min); LD50 i.v. in rats (mmol/kg): 6.6 (at 6 mL/min), 9.2 (at 1 mL/min) (Morisetti).
Melting point: mp 124°
Optical Rotation: [a]36520 -26.9° (c = 1.45 in water)
Absorption maximum: Abs max 257.8 nm (e 203)
Density: d20 1.22
Toxicity data: LD50 i.v. in mice (mmol/kg): 5.7 (at 1 mL/min), 7.9 (at 0.2 mL/min); LD50 i.v. in rats (mmol/kg): 6.6 (at 6 mL/min), 9.2 (at 1 mL/min) (Morisetti)
Therap-Cat: Diagnostic aid (MRI contrast agent).
Keywords: Diagnostic Aid (MRI Contrast Agent).