Title: Aminoglutethimide
CAS Registry Number: 125-84-8
CAS Name: 3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione
Synonyms: 2-(
p-aminophenyl)-2-ethylglutarimide; 3-ethyl-3-(
p-aminophenyl)-2,6-dioxopiperidine
Trademarks: Cytadren (Novartis); Orimeten (Novartis)
Molecular Formula: C13H16N2O2
Molecular Weight: 232.28
Percent Composition: C 67.22%, H 6.94%, N 12.06%, O 13.78%
Literature References: Aromatase inhibitor; also blocks adrenal steroidogenesis. Formerly used as anticonvulsant. Prepn: K. Hoffmann, E. Urech,
US 2848455 (1958 to Ciba). Mass spectrum: G. Ruecker, G. Bohn,
Arch. Pharm. 302, 204 (1969). Resolution and abs config of antipodes: N. Finch
et al., Experientia 31, 1002 (1975). Comprehensive description: H. Y. Aboul-Enein,
Anal. Profiles Drug Subs. 15, 35-69 (1986). Review of pharmacology and clinical use in Cushing's disease and breast cancer: R. J. Santen, R. I. Misbin,
Pharmacotherapy 1, 95-120 (1981); in prostate cancer: K. A. Havlin, D. L. Trump,
Cancer Treat. Res. 39, 83-96 (1988).
Properties: Crystals from methanol or ethyl acetate, mp 149-150°. Freely sol in most organic solvents; poorly sol in ethyl acetate, 0.1
N HCl and absolute ethanol; readily sol in acetone and 100% acetic acid. Practically insol in water.
Melting point: mp 149-150°
Therap-Cat: Adrenocortical suppressant; antineoplastic.
Keywords: Anticonvulsant; Antineoplastic (Hormonal); Antiadrenals; Aromatase Inhibitors; Aromatase Inhibitors; Adrenocortical Suppressant.
