Title: Meprednisone
CAS Registry Number: 1247-42-3
CAS Name: (16b)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione
Synonyms: 16b-methylprednisone
Trademarks: Betapred (Schering); Betapar (Parke-Davis); Betalone (Lepetit); Deltisona B
Molecular Formula: C22H28O5
Molecular Weight: 372.45
Percent Composition: C 70.95%, H 7.58%, O 21.48%
Literature References: Prepn: E. P. Oliveto
et al., J. Am. Chem. Soc. 80, 4428 (1958); D. Taub
et al., ibid. 4435; D. Taub
et al., ibid. 82, 4012 (1960); G. G. Nathansohn
et al., Experientia 17, 448 (1961);
GB 901092 (1962 to Scherico); R. Rausser, E. P. Oliveto,
US 3164618 (1965 to Schering).
Properties: Crystals, mp 200-205°. [a]D +200° (dioxane). uv max (methanol): 239 nm (E1%1cm 416).
Melting point: mp 200-205°
Optical Rotation: [a]D +200° (dioxane)
Absorption maximum: uv max (methanol): 239 nm (E1%1cm 416)
Derivative Type: 21-Acetate
Molecular Formula: C24H30O6
Molecular Weight: 414.49
Percent Composition: C 69.54%, H 7.30%, O 23.16%
Properties: mp 232-235°. [a]D +210° (dioxane). uv max (methanol): 238 nm (E1%1cm 358).
Melting point: mp 232-235°
Optical Rotation: [a]D +210° (dioxane)
Absorption maximum: uv max (methanol): 238 nm (E1%1cm 358)
Therap-Cat: Glucocorticoid.
Keywords: Glucocorticoid.
