Home > Name List By other > (2R,3R,4S, 5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol China

CAS No 123318-82-1 , (2R,3R,4S,
5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol Search by region : China

  • Name: (2R,3R,4S,
    5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
  • Synonyms: Clofarex;Clolar; Evoltra; clofarabinum;(2R,3R,4S,
    5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol; Cl-F-Ara-A; CAFdA; C1-F-Ara-A; clofarabina; 123318-82-1;
  • CAS Registry Number:
  • Melting Point: 228-2310C
  • Density: 2.12 g/cm3
  • Refractive index: 1.843
  • Safety Statements: Mutation data reported. When heated to decomposition it emits toxic vapors of NOx, F−, and Cl−.
  • Molecular Weight: 303.677443
  • InchiKey: WDDPHFBMKLOVOX-AYQXTPAHSA-N
  • InChI: InChI=1S/C10H11ClFN5O3/c11-10-15-7(13)5-8(16-10)17(2-14-5)9-4(12)6(19)3
    (1-18)20-9/h2-4,6,9,18-19H,1H2,(H2,13,15,16)/t3-,4+,6-,9-/m1/s1
  • Molecular Formula: C10H11ClFN5O3
  • Molecular Structure:CAS No:123318-82-1 (2R,3R,4S,<br />5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol

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References of (2R,3R,4S,
5R)-5-(6-amino-2-chloropurin-9-yl)-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
Title: Clofarabine
CAS Registry Number: 123318-82-1
CAS Name: 2-Chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine
Synonyms: 2-chloro-9-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)adenine; 2-chloro-2￠-arabinofluoro-2￠-deoxyadenosine; Cl-F-ara-A
Trademarks: Clolar (Genzyme)
Molecular Formula: C10H11ClFN5O3
Molecular Weight: 303.68
Percent Composition: C 39.55%, H 3.65%, Cl 11.67%, F 6.26%, N 23.06%, O 15.81%
Literature References: Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Prepn: K. A. Watanabe et al., EP 219829; eidem, US 4918179 (1987, 1990 both to Sloan-Kettering Inst. Cancer Res.); J. A. Montgomery et al., J. Med. Chem. 35, 397 (1992). Improved synthesis: W. E. Bauta et al., Org. Process Res. Dev. 8, 889 (2004). Antineoplastic activity: W. R. Waud et al., Nucleosides Nucleotides Nucleic Acids 19, 447 (2000). Clinical pharmacology: H. M. Kantarjian et al,. J. Clin. Oncol. 21, 1167 (2003). Clinical pharmacokinetics: V. Gandhi et al., Clin. Cancer Res. 9, 6335 (2003). Clinical evaluation in acute leukemia: H. Kantarjian et al., Blood 102, 2379 (2003); in pediatric patients: S. Jeha et al., ibid. 103, 784 (2004). Review of development: A. Sternberg, Curr. Opin. Invest. Drugs 4, 1479-1487 (2003); of mechanism of action and clinical experience: S. Faderl et al., Cancer 103, 1985-1995 (2005).
Properties: Crystals from water, mp 225-227° (Montgomery). Also reported as crystals from methanol, mp 237° (Bauta). uv max (water): 212, 263 nm (e 22500, 15989).
Melting point: mp 225-227° (Montgomery); crystals from methanol, mp 237° (Bauta)
Absorption maximum: uv max (water): 212, 263 nm (e 22500, 15989)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Purine Analogs.