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CAS No 12126-59-9 , Premarin Search by region : China

  • Name: Premarin
  • Synonyms: Sodium equilin sulfate; Sodium [(9S,13S,14S)-13-methyl-17-oxo-9,11,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthren-3-yl] sulfate;Conjugated Estrogens;Premarin;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: g/cm3
  • Safety Statements: Suspected carcinogen with experimental tumorigenic data. Poison by intraperitoneal route. Human reproductive effects by ingestion: changes in female fertility. Experimental teratogenic effects. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes.
  • Flash Point: °C
  • EINECS: 235-199-5
  • Molecular Weight: 370.40
  • InChI: InChI=1/C18H22O5S.Na/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);/q;+1/p-1/t14?,15?,16?,18-;/m0./s1
  • Molecular Formula: C18H19NaO5S
  • Molecular Structure:CAS No:12126-59-9 Premarin

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References of Premarin
Title: Conjugated Estrogens
CAS Registry Number: 12126-59-9
Synonyms: Conjugated equine estrogens; CEE
Trademarks: Premarin (Wyeth)
Literature References: Complex mixture of natural estrogens obtained from equine urine or synthetically from estrone and equilin. Principal components are sodium estrone sulfate and sodium equilin sulfate; also known to contain 17a-dihydroequilin, 17a-estradiol, and 17b-dihydroequilin as sodium sulfate conjugates. Purification from urine of pregnant mares: R. W. Bates, H. Cohen, US 2565115 (1951 to Squibb); E. T. Stiller, E. O'Keefe, US 2720483 (1955 to Olin Mathieson). HPLC determn of major components in serum: S. Y. Su et al., Biomed. Chromatogr. 6, 265 (1992). Review of pharmacokinetics and metabolism: B. R. Bhavnani, Proc. Soc. Exp. Biol. Med. 217, 6-16 (1998); of pharmacology and neuroprotective effects: idem, J. Steroid Biochem. Mol. Biol. 85, 473-482 (2003). Clinical assessment of efficacy and safety in combination with progestin in hormone replacement therapy: J. E. Rossouw et al., J. Am. Med. Assoc. 288, 321 (2002); of conjugated estrogens alone: G. L. Anderson et al., ibid. 291, 1701 (2004).
CAUTION: These substances are listed as known human carcinogens: Report on Carcinogens, Eleventh Edition (PB2005-104914, 2004) p III-115.
Therap-Cat: Estrogen.
Keywords: Estrogen; Steroidal.