Home > Name List By other > (2R,3S,4S, 5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol China

CAS No 121032-29-9 , (2R,3S,4S,
5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Search by region : China

  • Name: (2R,3S,4S,
    5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
  • Synonyms: Nelzarabine; 121032-29-9; GW-506U78; Arranon (GlaxoSmithKline);(2R,3S,4S,
    5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol; Arranon; ArranonG; Atriance; Arranon (TN);
  • CAS Registry Number:
  • Melting Point: 209-217 ºC
  • Density: 1.98 g/cm3
  • Refractive index: 1.829
  • Water Solubility: Slightly soluble in water
  • Molecular Weight: 297.2673
  • InchiKey: IXOXBSCIXZEQEQ-UHTZMRCNSA-N
  • InChI: InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4
    (2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1
  • Molecular Formula: C11H15N5O5
  • Molecular Structure:CAS No:121032-29-9 (2R,3S,4S,<br />5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

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References of (2R,3S,4S,
5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
Title: Nelarabine
CAS Registry Number: 121032-29-9
CAS Name: 9-b-D-Arabinofuranosyl-6-methoxy-9H-purin-2-amine
Synonyms: 2-amino-9-b-D-arabinofuranosyl-6-methoxy-9H-purine
Manufacturers' Codes: GW-506U78; 506U
Trademarks: Arranon (GSK)
Molecular Formula: C11H15N5O5
Molecular Weight: 297.27
Percent Composition: C 44.44%, H 5.09%, N 23.56%, O 26.91%
Literature References: Purine nucleoside; prodrug of guanine arabinoside. Prepn: T. A. Krenitsky et al., EP 294114 (1988 to Wellcome Foundation); idem, D. J. T. Porter, US 5424295 (1995 to Burroughs Wellcome); D. R. Averett et al., Antimicrob. Agents Chemother. 35, 851 (1991). HPLC determn of active metabolites in leukemia cells: C. O. Rodriguez Jr. et al., J. Chromatogr. B 745, 421 (2000). Mechanism of action study: idem, et al., Blood 102, 1842 (2003). Clinical pharmacokinetics: D. F. Kisor et al., J. Clin. Oncol. 18, 995 (2000). Clinical evaluation in T-cell malignancies: S. L. Berg et al., ibid. 23, 3376 (2005). Review of pharmacology and clinical experience: D. F. Kisor, Ann. Pharmacother. 39, 1056-1063 (2005).
Properties: mp 209-217° (dec). uv max (50 mM potassium phosphate buffer (pH 7.0)-ethanol (9:1, v/v)): 247.5, 279 nm (e 9100, 9300). [a]D20 +55.9° (c = 0.27 in DMF). Slightly sol to sol in water.
Melting point: mp 209-217°
Optical Rotation: [a]D20 +55.9° (c = 0.27 in DMF)
Absorption maximum: uv max (50 mM potassium phosphate buffer (pH 7.0)-ethanol (9:1, v/v)): 247.5, 279 nm (e 9100, 9300)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antimetabolites; Purine Analogs.