Home > Name List By 4 > 4H-Pyrido[3,2,1-jk]carbazol-11(8H)-one,5,6,9,10-tetrahydro-10-[(2-methyl-1H-imidazol-1-yl)methyl]-, (10R)-

CAS No 120635-74-7 , 4H-Pyrido[3,2,1-jk]carbazol-11(8H)-one,5,6,9,10-tetrahydro-10-[(2-methyl-1H-imidazol-1-yl)methyl]-, (10R)-

  • Name: 4H-Pyrido[3,2,1-jk]carbazol-11(8H)-one,5,6,9,10-tetrahydro-10-[(2-methyl-1H-imidazol-1-yl)methyl]-, (10R)-
  • Synonyms: CID6918107; D03495; DU-123265; KC-9946; Cilansetron [USAN:INN]; Cilansetron (USAN/INN);Calmactin; SureCN15950;4H-Pyrido[3,2,1-jk]carbazol-11(8H)-one,5,6,9,10-tetrahydro-10-[(2-methyl-1H-imidazol-1-yl)methyl]-, (10R)-; 120635-74-7;
  • CAS Registry Number:
  • Flash Point: 317°C
  • Boiling Point: 600.6°Cat760mmHg
  • Density: 1.36g/cm3
  • Refractive index: 1.729
  • Flash Point: 317°C
  • Molecular Weight: 319.40024
  • InchiKey: NCNFDKWULDWJDS-OAHLLOKOSA-N
  • InChI: InChI=1S/C20H21N3O/c1-13-21-9-11-22(13)12-15-7-8-17-18(20(15)24)16-6-2-
    4-14-5-3-10-23(17)19(14)16/h2,4,6,9,11,15H,3,5,7-8,10,12H2,
    1H3/t15-/m1/s1
  • Molecular Formula: C20H21N3O
  • Molecular Structure:CAS No:120635-74-7 4H-Pyrido[3,2,1-jk]carbazol-11(8H)-one,5,6,9,10-tetrahydro-10-[(2-methyl-1H-imidazol-1-yl)methyl]-, (10R)-

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120635-74-7 CILANSETRON

  • Hong kong Advanced Technology & Industrial Co., Ltd. [Manufacturer]
  • Tel: (852) 2390 2293/ (852) 2394 5546
  • Fax: (852) 2789 8314
  • Address: Unit B, 1/F., Cheong Shing Bldg.,
    17 Walnut St., Tai Kok Tsui, Kln,
    Hong Kong null,nullHong kong
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120635-74-7 CILANSETRON

  • United States LGM Pharma [Manufacturer]
  • Tel: 561-981-9994
  • Fax: 561-892-0580
  • Address: 922 Clint Moore Road
    Boca Raton, FL 33487 null,nullUnited States
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120635-74-7 Cilansetron

  • China Facus Pharmaceutical Co., Ltd. [Manufacturers]
  • Tel: +86-(574)-6237-8411
  • Fax: +86-(574)-6237-8410
  • Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800, Ningbo,ZhejiangChina
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References of 4H-Pyrido[3,2,1-jk]carbazol-11(8H)-one,5,6,9,10-tetrahydro-10-[(2-methyl-1H-imidazol-1-yl)methyl]-, (10R)-
Title: Cilansetron
CAS Registry Number: 120635-74-7
CAS Name: (10R)-5,6,9,10-Tetrahydro-10-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-pyrido[3,2,1-jk]carbazol-11(8H)-one
Synonyms: l-10[(2-methyl-1H-imidazol-1-yl)methyl]-5,6,8,9,10,11-hexahydro-4H-pyrido[3,2,1-jk]carbazol-11-one
Manufacturers' Codes: KC-9946
Molecular Formula: C20H21N3O
Molecular Weight: 319.40
Percent Composition: C 75.21%, H 6.63%, N 13.16%, O 5.01%
Literature References: Serotonin 5-HT3 receptor antagonist. Prepn: H. H. Haeck et al., EP 297651; eidem, US 4939136 (1989, 1990 both to Duphar Int. Res.); I. van Wijngaarden et al., J. Med. Chem. 36, 3693 (1993). Absolute configuration studies: P. G. Jones et al., Acta Crystallogr. E59, o38, o41 (2003). Pharmacology: A. Botella et al., Fundam. Clin. Pharmacol. 12, 619 (1998). Mechanism of action study: K. Hillsley et al., Neurosci. Lett. 278, 137 (2000). Clinical pharmacology: G. Stacher et al., Br. J. Clin. Pharmacol. 49, 429 (2000). Review of development and therapeutic potential: idem, Curr. Opin. Invest. Drugs 2, 1432-1436 (2001); of clinical experience: W. D. Chey, B. D. Cash, Expert Opin. Invest. Drugs 14, 185-193 (2005).
 
Derivative Type: Hydrochloride
CAS Registry Number: 120635-72-5; 209859-87-0 (monohydrate)
Trademarks: Calmactin (Solvay)
Molecular Formula: C20H21N3O.HCl
Molecular Weight: 355.86
Percent Composition: C 67.50%, H 6.23%, N 11.81%, O 4.50%, Cl 9.96%
Properties: Crystals, mp 226-228°. [a]D5 -5.0° (c = 1.8 in methanol).
Melting point: Crystals, mp 226-228°
Optical Rotation: [a]D5 -5.0° (c = 1.8 in methanol)
 
Therap-Cat: In treatment of irritable bowel syndrome.
Keywords: Serotonin Receptor Antagonist.