Home > Name List By n > N,N-dimethyl-2-[[(1R,3S,4R)-4,7, 7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine

CAS No 120444-71-5 , N,N-dimethyl-2-[[(1R,3S,4R)-4,7,
7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine

  • Name: N,N-dimethyl-2-[[(1R,3S,4R)-4,7,
    7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine
  • Synonyms: Ethanamine;Deramciclane [INN]; N,N-dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo(2.2.1)hept-2-yl)oxy)-;N,N-dimethyl-2-[[(1R,3S,4R)-4,7,
    7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine; 120444-71-5;
  • CAS Registry Number:
  • Flash Point: 110.6°C
  • Boiling Point: 375.2°Cat760mmHg
  • Density: 1.01g/cm3
  • Refractive index: 1.541
  • Flash Point: 110.6°C
  • Molecular Weight: 301.46624
  • InchiKey: QOBGWWQAMAPULA-RLLQIKCJSA-N
  • InChI: InChI=1S/C20H31NO/c1-18(2)17-11-12-19(18,3)20(15-17,
    22-14-13-21(4)5)16-9-7-6-8-10-16/h6-10,17H,11-15H2,1-5H3/t17-,19-,
    20+/m1/s1
  • Molecular Formula: C20H31NO
  • Molecular Structure:CAS No:120444-71-5 N,N-dimethyl-2-[[(1R,3S,4R)-4,7,<br />7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine

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120444-71-5 Deramciclane

  • Deramciclane, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
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120444-71-5 Deramciclane

  • Deramciclane, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
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120444-71-5 Ethanamine, N,N-dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo(2.2.1)hept-2-yl)oxy)-

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120444-71-5 DERAMCICLANE

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
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References of N,N-dimethyl-2-[[(1R,3S,4R)-4,7,
7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine
Title: Deramciclane
CAS Registry Number: 120444-71-5
CAS Name: N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine
Synonyms: (-)-[1R,2S,4R]-2-(2-dimethylaminoethoxy)-2-phenyl-1,7,7-trimethylbicyclo[2.2.1]heptane
Molecular Formula: C20H31NO
Molecular Weight: 301.47
Percent Composition: C 79.68%, H 10.36%, N 4.65%, O 5.31%
Literature References: Serotonin (5-HT2)-receptor antagonist. Prepn: BE 886579; Z. Budai et al., US 4342762 (1981, 1982 both to Egyt); L. Ladanyi et al., Chirality 11, 689 (1999). LC/MS/MS determn in plasma: A. Tolokán et al., J. Chromatogr. A 896, 279 (2000). Receptor binding profile and pharmacology: I. Gacsalyi et al., Drug Dev. Res. 40, 333 (1997). Clinical pharmacokinetics and tolerability: H. Kanerva et al., Int. J. Clin. Pharmacol. Ther. 37, 589 (1999). Clinical evaluation in generalized anxiety disorder: H. Naukkarinen et al., Eur. Neuropsychopharmcol. 15, 617 (2005). Review: S. Koks, E. Vasar, Curr. Opin. Invest. Drugs 3, 289-294 (2002).
Properties: Colorless oil. Log P (octanol/water): 5.9. Soly in water (25°): 0.0088 g/100 ml.
Log P: Log P (octanol/water): 5.9
 
Derivative Type: Fumarate
CAS Registry Number: 120444-72-6
Manufacturers' Codes: EGIS-3886
Molecular Formula: C20H31NO.C4H4O4
Molecular Weight: 417.54
Percent Composition: C 69.04%, H 8.45%, N 3.35%, O 19.16%
Properties: Crystals from DMF, mp 210-213°. [a]43620 -88.0° ± 1 (c = 0.4 in DMSO). Log P (octanol/water): 1.41. pKa 9.61.
Melting point: mp 210-213°
pKa: pKa 9.61
Optical Rotation: [a]43620 -88.0° ± 1 (c = 0.4 in DMSO)
Log P: Log P (octanol/water): 1.41
 
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Serotonin Receptor Antagonist.