Home > Name List By other > (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2, 3-b]thiopyran-2-sulfonamide

CAS No 120279-96-1 , (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,
3-b]thiopyran-2-sulfonamide

  • Name: (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,
    3-b]thiopyran-2-sulfonamide
  • Synonyms: Dorzolamide (INN);(4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,
    3-b]thiopyran-2-sulfonamide; AC1NR4NP; Dorzolamide (DZA); Trusopt; CHEBI:4702; Prestwick0_001116; Trusopt (TN);1cil;
  • CAS Registry Number:
  • Density: 1.53g/cm3
  • Molecular Weight: 324.44004
  • InchiKey: IAVUPMFITXYVAF-XPUUQOCRSA-N
  • InChI: InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,
    15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1
  • Molecular Formula: C10H16N2O4S3
  • Molecular Structure:CAS No:120279-96-1 (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,<br />3-b]thiopyran-2-sulfonamide

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References of (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,
3-b]thiopyran-2-sulfonamide
Title: Dorzolamide
CAS Registry Number: 120279-96-1
CAS Name: (4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
Molecular Formula: C10H16N2O4S3
Molecular Weight: 324.44
Percent Composition: C 37.02%, H 4.97%, N 8.63%, O 19.73%, S 29.65%
Literature References: Carbonic anhydrase inhibitor. Prepn: J. J. Baldwin et al., EP 296879; eidem, US 4797413 (1988, 1989 both to Merck & Co.). Mechanism of action study: R.-F. Wang et al., Arch. Ophthalmol. 109, 1297 (1991). HPLC determn in plasma and urine: B. K. Matuszewski, M. L. Constanzer, Chirality 4, 515 (1992). Clinical evaluations in glaucoma and ocular hypertension: E. A. Lippa et al., Ophthalmology 98, 308 (1991); E. A. Lippa et al., Arch. Ophthalmol. 110, 495 (1992).
 
Derivative Type: Hydrochloride
CAS Registry Number: 130693-82-2
Manufacturers' Codes: MK-507
Trademarks: Trusopt (Merck & Co.)
Molecular Formula: C10H16N2O4S3.HCl
Molecular Weight: 360.90
Percent Composition: C 33.28%, H 4.75%, N 7.76%, O 17.73%, S 26.65%, Cl 9.82%
Properties: mp 283-285°. [a]D24 -8.34° (c = 1 in methanol). Sol in water.
Melting point: mp 283-285°
Optical Rotation: [a]D24 -8.34° (c = 1 in methanol)
 
Therap-Cat: Antiglaucoma agent.
Keywords: Antiglaucoma; Carbonic Anhydrase Inhibitor.