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CAS No 120066-54-8 , Gadoteridol

  • Name: Gadoteridol
  • Synonyms: Gadoteridol;Gadolinium 10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecan-1,4,7-triacetate;
  • CAS Registry Number:
  • Melting Point: >225 deg C
  • Density: g/cm3
  • Molecular Weight: 558.68
  • InChI: InChI=1/C17H32N4O7.Gd/c1-14(22)10-18-2-4-19(11-15(23)24)6-8-21(13-17(27)28)9-7-20(5-3-18)12-16(25)26;/h14,22H,2-13H2,1H3,(H,23,24)(H,25,26)(H,27,28);/q;+3/p-3
  • Molecular Formula: C17H29GdN4O7
  • Molecular Structure:CAS No:120066-54-8 Gadoteridol

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120066-54-8 Gadoteridol

  • China Xiamen Mayah Pharma Co., Ltd. [Manufacturers]
  • Tel: +86-(592)-6806808
  • Fax: +86-(592)-6806809
  • Address: Room 523, Kechuang Building, NO.289, Road Wengjiaolu, Haicang, Xiamen, Fujian 361022, Xiamen,FujianChina
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120066-54-8 GADOTERIDOL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of Gadoteridol
Title: Gadoteridol
CAS Registry Number: 120066-54-8
CAS Name: [10-(2-Hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-)-N1,N4,N7,N10,O1,O4,O7,O10]gadolinium
Synonyms: 10-(2-hydroxypropyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid gadolinium complex; gadolinium(III) 1,4,7-tris(carboxymethyl)-10-(2￠-hydroxypropyl)-1,4,7,10-tetraazacyclododecane; Gd(HP-DO3A)
Manufacturers' Codes: SQ-32692
Molecular Formula: C17H29GdN4O7
Molecular Weight: 558.68
Percent Composition: C 36.55%, H 5.23%, Gd 28.15%, N 10.03%, O 20.05%
Literature References: Nonionic, low-osmolar paramagnetic gadolinium (III) chelate. Prepn: M. F. Tweedle et al., EP 292689; eidem, US 4885363 (1988, 1989 both to Squibb); D. D. Dischino et al., Inorg. Chem. 30, 1265 (1991). Biodistribution: P. Wedeking et al., Magn. Reson. Imaging 10, 641 (1992). RIA determn in biological fluids: M. D. Ogan et al., J. Pharm. Sci. 82, 475 (1993). Toxicological studies: R. A. Soltys, Invest. Radiol. 27, Suppl. 1, S7 (1992). Symposium on physicochemical properties, pharmacokinetics and clinical use in neurological disease: ibid. 1-63. Comprehensive description: K. Kumar et al., Anal. Profiles Drug Subs. Excip. 24, 209-241 (1996).
Properties: White solid obtained as an aggregate clump of fine needle-like microcrystals from methanol/acetone, mp >225°. Hydrophilic. At pH 7, log P (octanol/water): -3.68; (butanol/water): -1.98. Soly (mg/ml): water 737, methanol 119, isopropanol 41, dimethylformamide 10.1, acetonitrile 6.1, methylene chloride 5.2, ethyl acetate 0.5, acetone 0.4, hexane 0.2, toluene 0.3. uv max (water): 274 nm (am 2.5).
Melting point: mp >225°
Log P: log P (octanol/water): -3.68; (butanol/water): -1.98
Absorption maximum: uv max (water): 274 nm (am 2.5)
 
Derivative Type: Gadoteridol injection
Trademarks: ProHance (BMS)
Properties: Osmolality (37°): 630 mOsM/kg water. Viscosity (cP): 2.0 (20°), 1.3 (37°). d25 1.140. LD50 in mice, rats (mmol/kg): 11-14, >10 i.v. (Soltys).
Density: d25 1.140
Toxicity data: LD50 in mice, rats (mmol/kg): 11-14, >10 i.v. (Soltys)
 
Therap-Cat: Diagnostic aid (MRI contrast agent).
Keywords: Diagnostic Aid (MRI Contrast Agent).