Home > Name List By e > ethyl 6-[2-(4,4-dimethyl-2, 3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate

CAS No 118292-40-3 , ethyl
6-[2-(4,4-dimethyl-2,
3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate

  • Name: ethyl
    6-[2-(4,4-dimethyl-2,
    3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate
  • Synonyms: 118292-40-3;ethyl
    6-[2-(4,4-dimethyl-2,
    3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate; Zorac; Tazoral; Suretin; tazaroteno; Tazarotene [USAN:INN]; tazarotenum;Tazorac; Avage;
  • CAS Registry Number:
  • Density: 1.22 g/cm3
  • Refractive index: 1.624
  • Water Solubility: Well soluble in water
  • Molecular Weight: 351.46194
  • InchiKey: OGQICQVSFDPSEI-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H21NO2S/c1-4-24-20(23)16-7-9-17(22-14-16)8-5-15-6-10-19-18
    (13-15)21(2,3)11-12-25-19/h6-7,9-10,13-14H,4,11-12H2,1-3H3
  • Molecular Formula: C21H21NO2S
  • Molecular Structure:CAS No:118292-40-3 ethyl<br />6-[2-(4,4-dimethyl-2,<br />3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate

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References of ethyl
6-[2-(4,4-dimethyl-2,
3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate
Title: Tazarotene
CAS Registry Number: 118292-40-3
CAS Name: 6-[(3,4-Dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]-3-pyridinecarboxylic acid ethyl ester
Synonyms: ethyl 6-[2-(4,4-dimethylthiochroman-6-yl)ethynyl] nicotinate
Manufacturers' Codes: AGN-190168
Trademarks: Avage (Allergan); Tazorac (Allergan); Zorac (Allergan)
Molecular Formula: C21H21NO2S
Molecular Weight: 351.46
Percent Composition: C 71.76%, H 6.02%, N 3.99%, O 9.10%, S 9.12%
Literature References: Acetylenic retinoid prodrug converted to the active metabolite, tazarotenic acid, with selective affinity for retinoic acid receptors RARb and RARg. Prepn: R. A. S. Chandraratna, EP 284288; idem, US 5089509 (1988, 1992 both to Allergan). Clinical evaluation in psoriasis: T. Esgleyes-Ribot et al., J. Am. Acad. Dermatol. 30, 581 (1994). Clinical trial in treatment of photodamage: S. Kang et al., ibid. 52, 268 (2005). Review of pharmacokinetics and metabolism: D. D.-S. Tang-Liu et al., Clin. Pharmacokinet. 37, 273-287 (1999); of mechanism of action and treatment strategies: A. Roeder et al., Skin Pharmacol. Physiol. 17, 111-118 (2004).
Properties: White solid.
Therap-Cat: Antiacne; antipsoriatic. In treatment of photodamaged skin.
Keywords: Antiacne; Antipsoriatic.