Home > Name List By other > (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine China

CAS No 116539-59-4 , (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine Search by region : China

  • Name: (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine
  • Synonyms: duloxetine; 116539-59-4; (+)-isomer;Cymbalta;(3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine; LY 248686; (S)-Duloxetine; CHEBI:36795; Duloxetine [INN:BAN]; Yentreve;
  • CAS Registry Number:
  • Flash Point: 235.7 °C
  • Boiling Point: 466.2 °Cat760mmHg
  • Density: 1.158 g/cm3
  • Flash Point: 235.7 °C
  • Molecular Weight: 297.41456
  • InchiKey: ZEUITGRIYCTCEM-KRWDZBQOSA-N
  • InChI: InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-
    8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1
  • Molecular Formula: C18H19NOS
  • Molecular Structure:CAS No:116539-59-4 (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine

Select to

116539-59-4 2-Thiophenepropanamine,N-methyl-g-(1-naphthalenyloxy)-, (gS)-

Contact Supplier

116539-59-4 Duloxetine Hydrochloride

Contact Supplier

116539-59-4 Duloxetine Hydrochloride

  • China Shanghai Sunwise Chemical Co., Ltd. [Manufacturer]
  • Tel: +86-21-64063188
  • Fax: +86-21-64062858
  • Address: Shanghai Sunwise Chemical Co., Ltd.
    7G, No 1235 Wuzhong Road
    Shanghai P.R.China null,nullChina
Contact Supplier

116539-59-4 2-Thiophenepropanamine,N-methyl-g-(1-naphthalenyloxy)-, (gS)-

  • China Syntechem Co.,Ltd [Manufacturer]
  • Tel: +86-519-89882658
  • Fax: +86-519-8512 5369
  • Address: Syntechem Co.,Ltd
    18 South Zhulin Rd.
    Tianning district,Changzhou
    Jiangsu China 213022 null,nullChina
Contact Supplier

116539-59-4; 116539-60-7 Duloxetine

Contact Supplier

116539-59-4 Duloxetine Hydrochloride

  • China Shanghai Hanhong Chemical Co., Ltd. [Manufacturer, Trading Company, Agent]
  • Tel: +86-(21)-64762736, 64531573
  • Fax: +86-(21)-54291107
  • Address: 206-209, NO.1 Building , NO.245,Jiachuan Road, Xuhui District, Shanghai, Xuhui District,ShanghaiChina
Contact Supplier

116539-59-4 Duloxetine HCl

  • Duloxetine HCl
  • China Shanghai Synnad Chemical Co., Ltd. [Importer/Exporter]
  • Tel: 86 21 5109 7911
  • Fax: 86 21 5109 7955
  • Address: B-5 Ecust Science Park, No. 18, Lane 1305, Hua Jing Road, Shanghai 200231 China Shanghai,ShanghaiChina
Contact Supplier

116539-59-4 2-Thiophenepropanamine,N-methyl-g-(1-naphthalenyloxy)-, (gS)-

  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
  • Fax: 571 88233092
  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China null,ZheJiangChina
Contact Supplier

116539-59-4; 116539-60-7 DULOXETINE

  • China HANGZHOU THINK CHEMICAL CO. [Manufacturer]
  • Tel: +86-571-81956191/ +86-571-81956192
  • Fax: +86-571-81956190
  • Address: 425 MOGAN HILL ROAD ,
    HANGZHOU, 310011 CHINA null,nullChina
Contact Supplier

116539-59-4 Duloxetine Hydrochloride

  • China Goly Chemical Co., Ltd. [Manufacturers]
  • Tel: +86-(632)-6163187
  • Fax: +86-(632)-5100028
  • Address: Room No.6.Building21 LongXingBeiLi,ShiZhong, ZaoZhua, ShanDong 277102, ZaoZhuang,ShanDongChina
Contact Supplier

Select to

References of (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine
Title: Duloxetine
CAS Registry Number: 116539-59-4
CAS Name: (gS)-N-Methyl-g-(1-naphthalenyloxy)-2-thiophenepropanamine
Synonyms: (+)-(S)-N-methyl-g-(1-naphthyloxy)-2-thiophenepropylamine; (+)-N-methyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propanamine
Manufacturers' Codes: LY-248686
Molecular Formula: C18H19NOS
Molecular Weight: 297.41
Percent Composition: C 72.69%, H 6.44%, N 4.71%, O 5.38%, S 10.78%
Literature References: Dual serotonin and norepinephrine reuptake inhibitor (SNRI). Prepn: D. W. Robertson et al., EP 273658; eidem, US 5023269 (1988, 1991 both to Lilly); and abs config: J. Deeter et al., Tetrahedron Lett. 31, 7101 (1990). Improved process: R. A. Berglund, US 5362886 (1994 to Lilly). Pharmacology: D. T. Wong et al., Neuropsychopharmacology 8, 23 (1993). Neurochemical effects in vivo: R. W. Fuller et al., J. Pharmacol. Exp. Ther. 269, 132 (1994). Determn of chiral purity: E. C. Rickard, R. J. Bopp, J. Chromatogr. A 680, 609 (1994). Clinical pharmacokinetics: A. Sharma et al., J. Clin. Pharmacol. 40, 161 (2000). Clinical trial in stress incontinence: P. A. Norton et al., Am. J. Obstet. Gynecol. 187, 40 (2002); in depression: M. J. Detke et al., J. Psychiatr. Res. 36, 383 (2002).
 
Derivative Type: Hydrochloride
CAS Registry Number: 136434-34-9
Trademarks: Ariclaim (Lilly); Cymbalta (Lilly); Yentreve (Lilly)
Molecular Formula: C18H19NOS.HCl
Molecular Weight: 333.88
Percent Composition: C 64.75%, H 6.04%, N 4.20%, O 4.79%, S 9.60%, Cl 10.62%
Properties: White solid. pKa in DMF-water (66:34): 9.6.
pKa: pKa in DMF-water (66:34): 9.6
 
Therap-Cat: Antidepressant; in treatment of stress urinary incontinence.
Keywords: Antidepressant; Serotonin Noradrenaline Reuptake Inhibitor (SNRI).