Home > Name List By other > (2R)-2-[2-[3-[2-(1, 3-benzodioxol-5-yloxy)ethyl-methylamino]propoxy]-5-methoxyphenyl]-4- methyl-1,4-benzothiazin-3-one

CAS No 116476-13-2 , (2R)-2-[2-[3-[2-(1,
3-benzodioxol-5-yloxy)ethyl-methylamino]propoxy]-5-methoxyphenyl]-4-
methyl-1,4-benzothiazin-3-one

  • Name: (2R)-2-[2-[3-[2-(1,
    3-benzodioxol-5-yloxy)ethyl-methylamino]propoxy]-5-methoxyphenyl]-4-
    methyl-1,4-benzothiazin-3-one
  • Synonyms: (2R)-2-[2-[3-[2-(1,
    3-benzodioxol-5-yloxy)ethyl-methylamino]propoxy]-5-methoxyphenyl]-4-
    methyl-1,4-benzothiazin-3-one;Semotiadil; Semotiadilum; 116476-13-2; Semotiadilum [INN-Latin]; Semotiadil [INN];
  • CAS Registry Number:
  • Flash Point: 393.7°C
  • Boiling Point: 727.3°Cat760mmHg
  • Density: 1.263g/cm3
  • Refractive index: 1.61
  • Flash Point: 393.7°C
  • Molecular Weight: 536.63918
  • InchiKey: RKXVEXUAWGRFNP-MUUNZHRXSA-N
  • InChI: InChI=1S/C29H32N2O6S/c1-30(14-16-34-21-10-12-25-26(18-21)37-19-36-25)13-
    6-15-35-24-11-9-20(33-3)17-22(24)28-29(32)31(2)23-7-4-5-8-27(23)38-28/
    h4-5,7-12,17-18,28H,6,13-16,19H2,1-3H3/t28-/m1/s1
  • Molecular Formula: C29H32N2O6S
  • Molecular Structure:CAS No:116476-13-2 (2R)-2-[2-[3-[2-(1,<br />3-benzodioxol-5-yloxy)ethyl-methylamino]propoxy]-5-methoxyphenyl]-4-<br />methyl-1,4-benzothiazin-3-one

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116476-13-2 Semotiadil

  • United States LGM Pharma [Manufacturer]
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116476-13-2 SEMOTIADIL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
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References of (2R)-2-[2-[3-[2-(1,
3-benzodioxol-5-yloxy)ethyl-methylamino]propoxy]-5-methoxyphenyl]-4-
methyl-1,4-benzothiazin-3-one
Title: Semotiadil
CAS Registry Number: 116476-13-2
CAS Name: (2R)-2-[2-[3-[[2-(1,3-Benzodioxol-5-yloxy)ethyl]methylamino]propoxy]-5-methoxyphenyl]-4-methyl-2H-1,4-benzothiazin-3(4H)-one
Synonyms: (+)-(R)-3,4-dihydro-2-[5-methoxy-2-[3-[N-methyl-[N-2-[3,4-(methylenedioxy)phenoxy]ethyl]amino]propoxy]phenyl]-4-methyl-3-oxo-2H-1,4-benzothiazine; sesamodil
Manufacturers' Codes: DS-4823
Molecular Formula: C29H32N2O6S
Molecular Weight: 536.64
Percent Composition: C 64.91%, H 6.01%, N 5.22%, O 17.89%, S 5.98%
Literature References: Benzothiazine calcium antagonist. Prepn: J. Iwao et al., WO 8700838; eidem, US 4786635 (1987, 1988 both to Santen). Synthesis: M. Fujita et al., J. Med. Chem. 33, 1898 (1990). LC determn in plasma: K. Morishima et al., J. Chromatogr. 527, 381 (1990). Molecular conformation and crystal structure: A. Ota et al., Chem. Pharm. Bull. 41, 1681 (1993). Electrophysiology: N. Miyawaki et al., J. Cardiovasc. Pharmacol. 16, 769 (1990); and antiarrhythmic effects: eidem, Drug Dev. Res. 22, 293 (1991). Antihypertensive effects in rats: A. Kanda, H. Hashimoto, Jpn. J. Pharmacol. 63, 121 (1993). Mechanism of action study: K. Murakami et al., J. Cardiovasc. Pharmacol. 25, 262 (1995).
 
Derivative Type: Fumarate
CAS Registry Number: 116476-14-3
Manufacturers' Codes: SD-3211
Molecular Formula: C29H32N2O6S.C4H4O4
Molecular Weight: 652.71
Percent Composition: C 60.72%, H 5.56%, N 4.29%, O 24.51%, S 4.91%
Properties: Crystals from EtOH, mp 134-135°. [a]D25 +195° (in DMSO).
Melting point: mp 134-135°
Optical Rotation: [a]D25 +195° (in DMSO)
 
Therap-Cat: Antihypertensive; antianginal.
Keywords: Antianginal; Antihypertensive; Calcium Channel Blocker; Arylalkylamines.