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CAS No 115575-11-6 , 1H-Benzimidazole,6-[(3-chlorophenyl)-1H-imidazol-1-ylmethyl]-

  • Name: 1H-Benzimidazole,6-[(3-chlorophenyl)-1H-imidazol-1-ylmethyl]-
  • Synonyms: 1H-Benzimidazole,6-[(3-chlorophenyl)-1H-imidazol-1-ylmethyl]-;1H-Benzimidazole,5-[(3-chlorophenyl)-1H-imidazol-1-ylmethyl]- (9CI); Liarozole;
  • CAS Registry Number:
  • Flash Point: 303.5°C
  • Boiling Point: 578.2°Cat760mmHg
  • Density: 1.36g/cm3
  • Flash Point: 303.5°C
  • Molecular Weight: 0
  • InChI: InChI=1/C17H13ClN4.ClH/c18-14-3-1-2-12(8-14)17(22-7-6-19-11-22)13-4-5-15-16(9-13)21-10-20-15;/h1-11,17H,(H,20,21);1H
  • Molecular Formula: C17H13 Cl N4
  • Molecular Structure:CAS No:115575-11-6 1H-Benzimidazole,6-[(3-chlorophenyl)-1H-imidazol-1-ylmethyl]-

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115575-11-6 Liarozole

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115575-11-6 LIAROZOLE

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References of 1H-Benzimidazole,6-[(3-chlorophenyl)-1H-imidazol-1-ylmethyl]-
Title: Liarozole
CAS Registry Number: 115575-11-6
CAS Name: 5-[(3-Chlorophenyl)-1H-imidazol-1-ylmethyl]-1H-benzimidazole
Synonyms: (±)-5-(m-chloro-a-imidazol-1-ylbenzyl)benzimidazole
Molecular Formula: C17H13ClN4
Molecular Weight: 308.76
Percent Composition: C 66.13%, H 4.24%, Cl 11.48%, N 18.15%
Literature References: Inhibits cytochrome P450-dependent enzymes involved in steroid biosynthesis and retinoic acid catabolism. Prepn: A. H. M. Raeymaekers et al., EP 260744; eidem, US 4859684 (1988, 1989 both to Janssen). In vivo antitumor activity: R. Van Ginckel et al., Prostate 16, 313 (1990). Pharmacology and effect on steroid synthesis: J. Bruynseels et al., ibid., 345; and effect on retinoic acid: R. De Coster et al., J. Steroid Biochem. Mol. Biol. 43, 197 (1992). Clinical evaluation in prostate cancer: C. Mahler et al., Cancer 71, 1068 (1993); in psoriasis: P. Dockx et al., Br. J. Dermatol. 133, 426 (1995); in combination therapy for malignant brain tumors: M. E. Westarp et al., Onkologie 16, 22 (1993).
Properties: mp 108.2°.
Melting point: mp 108.2°
 
Derivative Type: Fumarate
CAS Registry Number: 145858-52-2
Manufacturers' Codes: R-85246
Trademarks: Liazal (Janssen)
Molecular Formula: 2C17H13ClN4.3C4H4O4
Molecular Weight: 965.75
Percent Composition: C 57.21%, H 3.97%, Cl 7.34%, N 11.60%, O 19.88%
 
Derivative Type: Hydrochloride
CAS Registry Number: 145858-50-0
Manufacturers' Codes: R-75251
Molecular Formula: C17H13ClN4.HCl
Molecular Weight: 345.23
Percent Composition: C 59.14%, H 4.09%, Cl 20.54%, N 16.23%
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic.