Title: Brain Natriuretic Peptide
CAS Registry Number: 114471-18-0
CAS Name: Brain natriuretic factor
Synonyms: B-type natriuretic peptide; BNP
Literature References: Peptide hormone structurally and physiologically similar to atrial natriuretic peptide,
q.v. Originally discovered in mammalian brain, subsequently found to be produced primarily by the cardiac ventricle in response to hemodynamic stress. Amino acid sequence shows a marked interspecies diversity; the normal circulating form in humans contains 32 amino acid residues. Isoln from porcine brain: T. Sudoh
et al., Nature 332, 78 (1988). Cloning of human BNP precursor:
idem et al., Biochem. Biophys. Res. Commun. 159, 1427 (1989). Direct isoln from human heart: Y. Kambayashi
et al., FEBS Lett. 259, 341 (1990). Use in prognosis of risk in acute coronary syndromes: J. A. de Lemos
et al., N. Engl. J. Med. 345, 1014 (2001); in diagnosis of congestive heart failure: A. S. Maisel
et al., ibid. 347, 161 (2002).
Review: N. C. Davidson, A. D. Struthers,
J. Hypertens. 12, 329-336 (1994); T. Takeda, M. Kohno,
Hypertens. Res. 18, 259-266 (1995); of pathophysiological significance: M. Yoshibayashi
et al., Eur. J. Endocrinol. 135, 265-268 (1996); of clinical experience: N. Valli
et al., J. Lab. Clin. Med. 134, 437-444 (1999).
Derivative Type: Nesiritide
CAS Registry Number: 124584-08-3
Synonyms: Human brain natriuretic peptide-32; natriuretic factor-32 (human brain clone lhBNP57)
Trademarks: Natrecor (Scios)
Literature References: Clinical hemodynamic effects: L. S. Marcus
et al., Circulation 94, 3184 (1996). Clinical trial in congestive heart failure: W. S. Colucci
et al., N. Engl. J. Med. 343, 246 (2000).
Therap-Cat: In treatment of congestive heart failure.
