Home > Name List By n > N-[2-(3, 4-dimethoxyphenyl)ethyl]-N-methyl-3-[4-(2-propan-2-ylindolizin-1-yl) sulfonylphenoxy]propan-1-amine

CAS No 114432-13-2 , N-[2-(3,
4-dimethoxyphenyl)ethyl]-N-methyl-3-[4-(2-propan-2-ylindolizin-1-yl)
sulfonylphenoxy]propan-1-amine

  • Name: N-[2-(3,
    4-dimethoxyphenyl)ethyl]-N-methyl-3-[4-(2-propan-2-ylindolizin-1-yl)
    sulfonylphenoxy]propan-1-amine
  • Synonyms: Fantofaronum [INN-Latin]; SR-33557;N-[2-(3,
    4-dimethoxyphenyl)ethyl]-N-methyl-3-[4-(2-propan-2-ylindolizin-1-yl)
    sulfonylphenoxy]propan-1-amine; Fantofarona [INN-Spanish];
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.16g/cm3
  • Refractive index: 1.573
  • Flash Point: °C
  • Molecular Weight: 550.70882
  • InchiKey: ITAMRBIZWGDOHW-UHFFFAOYSA-N
  • InChI: InChI=1S/C31H38N2O5S/c1-23(2)27-22-33-18-7-6-9-28(33)31(27)39(34,
    35)26-13-11-25(12-14-26)38-20-8-17-32(3)19-16-24-10-15-29(36-4)30(21-24)
    37-5/h6-7,9-15,18,21-23H,8,16-17,19-20H2,1-5H3
  • Molecular Formula: C31H38N2O5S
  • Molecular Structure:CAS No:114432-13-2 N-[2-(3,<br />4-dimethoxyphenyl)ethyl]-N-methyl-3-[4-(2-propan-2-ylindolizin-1-yl)<br />sulfonylphenoxy]propan-1-amine

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114432-13-2 Fantofarone

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114432-13-2 FANTOFARONE

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1/1
References of N-[2-(3,
4-dimethoxyphenyl)ethyl]-N-methyl-3-[4-(2-propan-2-ylindolizin-1-yl)
sulfonylphenoxy]propan-1-amine
Title: Fantofarone
CAS Registry Number: 114432-13-2
CAS Name: 3,4-Dimethoxy-N-methyl-N-[3-[4-[[2-(1-methylethyl)-1-indolizinyl]sulfonyl]phenoxy]propyl]benzeneethanamine
Synonyms: 2-isopropyl-1-[4-[3-[N-methyl-N-(3,4-dimethoxy-b-phenethyl)amino]propyloxy]benzenesulfonyl]indolizine
Manufacturers' Codes: SR-33557
Molecular Formula: C31H38N2O5S
Molecular Weight: 550.71
Percent Composition: C 67.61%, H 6.95%, N 5.09%, O 14.53%, S 5.82%
Literature References: Indolizinsulfone calcium channel blocker. Prepn: J. Gubin et al., EP 235111; J. Gubin et al., US 4957925 (1987, 1990 both to Sanofi); eidem, J. Med. Chem. 35, 981 (1992). Binding studies: A. Schmid et al., Mol. Pharmacol. 35, 766 (1989); B. A. Kenny et al., Br. J. Pharmacol. 108, 93 (1993). X-ray structure and electronic properties: V. J. Gibon et al., Eur. J. Med. Chem. 27, 485 (1992). Pharmacokinetics: E. Bellissant et al., Eur. J. Clin. Pharmacol. 41, 329 (1991). Review of pharmacology and clinical evaluations: P. Chatelain et al., Cardiovasc. Drug Rev. 9, 123-146 (1991).
Properties: Monoclinic colorless sheets from diisopropyl ether/ CHCl2, mp 82-83°. dz 1.21 g/cm3. Sol in all organic solvents, in water at 0.06%. pKa 8.34 ± 0.05.
Melting point: mp 82-83°
pKa: pKa 8.34 ± 0.05
Density: dz 1.21 g/cm3
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Calcium Channel Blocker.