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CAS No 114-86-3 , 1-(diaminomethylidene)-2-(2-phenylethyl)guanidine

  • Name: 1-(diaminomethylidene)-2-(2-phenylethyl)guanidine
  • Synonyms: Cronoformin;1-(diaminomethylidene)-2-(2-phenylethyl)guanidine; Phenylethylbiguanide; Fenformin; Lentobetic; Normoglucina;Phenformine; Phenformix; Glukopostin; Fenfoduron;
  • CAS Registry Number:
  • Melting Point: 174 - 175
  • Density: 1.24 g/cm3
  • Refractive index: 1.62
  • Safety Statements: S36
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 204-057-4
  • Molecular Weight: 205.2596
  • InchiKey: ICFJFFQQTFMIBG-UHFFFAOYSA-N
  • InChI: InChI=1S/C10H15N5/c11-9(12)15-10(13)14-7-6-8-4-2-1-3-5-8/h1-5H,6-7H2,
    (H6,11,12,13,14,15)
  • Risk Statements: R22
  • Molecular Formula: C10H15N5
  • Molecular Structure:CAS No:114-86-3 1-(diaminomethylidene)-2-(2-phenylethyl)guanidine

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References of 1-(diaminomethylidene)-2-(2-phenylethyl)guanidine
Title: Phenformin
CAS Registry Number: 114-86-3
CAS Name: N-(2-Phenylethyl)imidodicarbonimidic diamide
Synonyms: 1-phenethylbiguanide; phenethyldiguanide; N￠-b-phenethylformamidinyliminourea; fenformin; fenormin; b-PEBG; PEDG
Molecular Formula: C10H15N5
Molecular Weight: 205.26
Percent Composition: C 58.51%, H 7.37%, N 34.12%
Literature References: Prepn: Shapiro et al., J. Am. Chem. Soc. 81, 2220 (1959); Shapiro, Freedman, US 2961377; US 3057780 (1960, 1962 both to U.S.V.). Metabolism: R. Beckmann, Diabetologia 3, 368 (1967). Association with lactic acidosis in diabetic patients: R. I. Misbin, Ann. Intern. Med. 87, 591 (1977). Toxicity study: G. Proske et al., Arzneim.-Forsch. 12, 314 (1962). Comprehensive description: J. E. Moody, Anal. Profiles Drug Subs. 4, 319-332 (1975). Review of phenformin-induced lactic acidosis: M. E. McGuinness, R. L. Talbert, Ann. Pharmacother. 27, 1183-1187 (1993).
 
Derivative Type: Hydrochloride
CAS Registry Number: 834-28-6
Trademarks: Insoral (Spofa)
Molecular Formula: C10H15N5.HCl
Molecular Weight: 241.72
Percent Composition: C 49.69%, H 6.67%, N 28.97%, Cl 14.67%
Properties: Crystals from isopropanol, mp 175-178°. Sol in water; pH (0.1M aq soln): 6.7. LD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske).
Melting point: mp 175-178°
Toxicity data: LD50 in mice (mg/kg): 19 i.v., 450 orally; in rats: 1050 orally; in guinea pigs: 47 orally, 19 s.c. (Proske)
 
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Biguanides.