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CAS No 114-07-8 , Erythromycin Search by region : Canada

  • Name: Erythromycin
  • Synonyms: Erythromast; Erymax; Erythroguent; Robimycin; T-Stat; Erythromast 36; L-alpha-Egg-phosphatidylcholine; ERY-PED; Erythromid; E-Base; Ilotycin;Erythromycin; Erythrocin; Torlamicna; Eritrocina; Drmysin; Erycin; Pediamycin; Ilocap; Ak-Mycin; Eryacne; ERYC; Ery Derm; ERY-TAB; EMU; Erthrogran;Abomacetin; Ilosone; Erypar; P.C.E.; Emgel; Retcin; Erycette; E.E.S; Stiemycin; Inderm; Erycinum; Wintrocin; Gallimycin; USP; Staticin; Statcin;(-)-Erythromycin; Aknin; Eritocina; Torlamicina; Ergel; Erythro; E-mycin; Erycen; Wyamycin-s;
  • CAS Registry Number:
  • Transport: MAC
  • Melting Point: 138-140 ºC
  • Flash Point: 448.8°C
  • Boiling Point: 818.4°Cat760mmHg
  • Density: 1.2g/cm3
  • Refractive index: -74 ° (C=2, EtOH)
  • Alpha: -74.5 º (C=2, ETHANOL)
  • Water Solubility: <1 mg/mL at 22 C , >=100 mg/mL at 22 C (in ethanol)
  • Safety Statements: R42/43
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 448.8°C
  • EINECS: 204-040-1
  • Molecular Weight: 733.93
  • InChI: InChI=1/C37H67NO13/c1-14-25-37(10,45)30(41)20(4)27(39)18(2)16-35(8,44)32(51-34-28(40)24(38(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-36(9,46-13)31(42)23(7)48-26/h18-26,28-32,34,40-42,44-45H,14-17H2,1-13H3/t18-,19+,20+,21+,22-,23+,24-,25-,26+,28+,29+,30-,31+,32-,34-,35-,36-,37-/m1/s1
  • Risk Statements: S24;S37;S45
  • Molecular Formula: C37H67NO13
  • Molecular Structure:CAS No:114-07-8 Erythromycin

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114-07-8 ERYTHROMYCIN

  • Canada Synth?se AptoChem Inc. [Manufacturer]
  • Tel: 514-496-4252
  • Fax: 514-496-4253
  • Address: Synth?se AptoChem Inc.
    6100 Royalmount Ave
    Montreal, QC
    Canada
    H4P 2R2 null,nullCanada
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114-07-8 Erythromycin

  • Canada Onbio Inc. [Manufacturers]
  • Tel: +1-(905)707-1241 ++1.905.780.1700
  • Fax: +1-(905)707-0041
  • Address: 26 Benson Avenue, Suite 101, Richmond Hill, Ontario, Canada L4C 4E6 Richmond Hill,OntariCanada
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References of Erythromycin
Title: Erythromycin
CAS Registry Number: 114-07-8
Synonyms: E-Base; E-Mycin; Erythromycin A
Trademarks: Aknemycin (Hermal); Aknin (Lichtenstein); Emgel (GSK); Ery-Derm (Abbott); Erymax (Merz); Ery-Tab (Abbott); Erythromid (Abbott); ERYC (Warner-Chilcott); Erycen (APS); Erycin (Nycomed); Erycinum (Cytochemia); Ermysin (Orion); Gallimycin (Bimeda); Ilotycin (Lilly); Inderm (Dermapharm); PCE (Abbott); Retcin (DDSA); Staticin (Westwood); Stiemycin (Stiefel)
Molecular Formula: C37H67NO13
Molecular Weight: 733.93
Percent Composition: C 60.55%, H 9.20%, N 1.91%, O 28.34%
Literature References: Antibiotic substance produced by a strain of Streptomyces erythreus (Waksman) Waksman & Henrici, found in a soil sample from the Philippine Archipelago. Isoln: McGuire et al., Antibiot. Chemother. 2, 281 (1952); Bunch, McGuire, US 2653899 (1953 to Lilly); Clark, Jr., US 2823203 (1958 to Abbott). Properties: Flynn et al., J. Am. Chem. Soc. 76, 3121 (1954). Solubility data: Weiss et al., Antibiot. Chemother. 7, 374 (1957). Structure: Wiley et al., J. Am. Chem. Soc. 79, 6062 (1957). Configuration: Hofheinz, Grisebach, Ber. 96, 2867 (1963); Harris et al., Tetrahedron Lett. 1965, 679. There are three erythromycins produced during fermentation, designated A, B, and C; A is the major and most important component. Erythromycins A and B contain the same sugar moieties, desosamine, q.v., and cladinose (3-O-methylmycarose). They differ in position 12 of the aglycone, erythronolide, A having an hydroxyl substituent. Component C contains desosamine and the same aglycone present in A but differs by the presence of mycarose, q.v., instead of cladinose. Structure of B: P. F. Wiley et al., J. Am. Chem. Soc. 79, 6070 (1957); of C: eidem, ibid. 6074. Synthesis of the aglycone, erythronolide B: E. J. Corey et al., ibid. 100, 4618, 4620 (1978); of erythronolide A: eidem, ibid. 101, 7131 (1979). Asymmetric total synthesis of erythromycin A: R. B. Woodward et al., ibid. 103, 3215 (1981). NMR spectrum of A: D. J. Ager, C. K. Sood, Magn. Reson. Chem. 25, 948 (1987). HPLC determn in plasma: W. Xiao et al., J. Chromatogr. B 817, 153 (2005). Biosynthesis: Martin, Goldstein, Prog. Antimicrob. Anticancer Chemother., Proc. 6th Int. Congr. Chemother. II, 1112 (1970); Martin et al., Tetrahedron 31, 1985 (1975). Cloning and expression of clustered biosynthetic genes: R. Stanzak et al., Biotechnology 4, 229 (1986). Reviews: T. J. Perun in Drug Action and Drug Resistance in Bacteria 1, S. Mitsuhashi, Ed. (University Park Press, Baltimore, 1977) pp 123-152; Oleinick in Antibiotics vol. 3, J. W. Corcoran, F. E. Hahn, Eds. (Springer-Verlag, New York, 1975) pp 396-419; Infection 10, Suppl. 2, S61-S118 (1982). Comprehensive description: W. L. Koch, Anal. Profiles Drug Subs. 8, 159-177 (1979).
Properties: Hydrated crystals from water, mp 135-140°, resolidifies with second mp 190-193°. Melting point taken after drying at 56° and 8 mm. [a]D25 -78° (c = 1.99 in ethanol). uv max (pH 6.3): 280 nm (e 50). pKa1 8.8. Basic reaction. Readily forms salts with acids. Soly in water: ~2 mg/ml. Freely sol in alcohols, acetone, chloroform, acetonitrile, ethyl acetate. Moderately sol in ether, ethylene dichloride, amyl acetate.
Melting point: mp 135-140°, resolidifies with second mp 190-193°
pKa: pKa1 8.8
Optical Rotation: [a]D25 -78° (c = 1.99 in ethanol)
Absorption maximum: uv max (pH 6.3): 280 nm (e 50)
 
Derivative Type: Ethylsuccinate
CAS Registry Number: 41342-53-4
Trademarks: Anamycin (Chephasaar); Arpimycin (Rosemont); E.E.S. (Abbott); Eritrocina (Abbott); Eryliquid (Linden); Eryped (Abbott); Erythroped (Abbott); Esinol (Toyama); Monomycin (Grñenthal); Paediathrocin (Abbott); Pediamycin (Abbott); Refkas (Maruko)
Molecular Formula: C43H75NO16
Molecular Weight: 862.05
Percent Composition: C 59.91%, H 8.77%, N 1.62%, O 29.70%
Literature References: Prepn: GB 830846; R. K. Clark, US 2967129 (1960, 1961 both to Abbott).
Properties: Hydrated crystals from acetone + water, mp 109-110°. [a]D -42.5°.
Melting point: mp 109-110°
Optical Rotation: [a]D -42.5°
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); Macrolides.