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CAS No 1134-47-0 , 4-amino-3-(4-chlorophenyl)butanoic acid

  • Name: 4-amino-3-(4-chlorophenyl)butanoic acid
  • Synonyms: 1134-47-0;4-amino-3-(4-chlorophenyl)butanoic acid; Pms-Baclofen; Lioresal Intrathecal; DL-Baclofen; Kemstro;Lioresal; 4-Amino-3-(4-chlorophenyl)butanoic acid; Baclon;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 208-210ºC
  • Flash Point: 174.1ºC
  • Boiling Point: 364.3ºC at 760 mmHg
  • Density: 1.285 g/cm3
  • Refractive index: 1.576
  • Water Solubility: 1 M HCl: 50 mg/mL
  • Safety Statements: R61;R25;R36/37/38;R42/43
  • Hazard Symbols: T: Toxic;
  • Flash Point: 174.1ºC
  • EINECS: 214-486-9
  • Molecular Weight: 213.66078
  • InchiKey: KPYSYYIEGFHWSV-UHFFFAOYSA-N
  • InChI: InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,
    12H2,(H,13,14)
  • Risk Statements: S52;S22;S36/37/39;S45
  • Molecular Formula: C10H12ClNO2
  • Molecular Structure:CAS No:1134-47-0 4-amino-3-(4-chlorophenyl)butanoic acid

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References of 4-amino-3-(4-chlorophenyl)butanoic acid
Title: Baclofen
CAS Registry Number: 1134-47-0
CAS Name: b-(Aminomethyl)-4-chlorobenzenepropanoic acid
Synonyms: b-(aminomethyl)-p-chlorohydrocinnamic acid; g-amino-b-(p-chlorophenyl)butyric acid; b-(4-chlorophenyl)GABA
Manufacturers' Codes: Ba-34647
Trademarks: Baclon (Leiras); Clofen (Alphapharm); Lioresal (Novartis)
Molecular Formula: C10H12ClNO2
Molecular Weight: 213.66
Percent Composition: C 56.21%, H 5.66%, Cl 16.59%, N 6.56%, O 14.98%
Literature References: Specific GABA-B receptor agonist. Prepn: NL 6407755; H. Keberle et al., US 3471548 (1965, 1969 both to Ciba). Toxicity study: T. Tadokoro et al., Osaka Daigaku Igaku Zasshi 28, 265 (1976), C.A. 88, 183016u (1978). Comprehensive description: S. Ahuja, Anal. Profiles Drug Subs. 14, 527-548 (1985). Review of pharmacology and therapeutic efficacy in spasticity: R. N. Brogden et al., Drugs 8, 1-14 (1974); of intrathecal use in spinal cord injury: K. S. Lewis, W. M. Mueller, Ann. Pharmacother. 27, 767-774 (1993). Clinical evaluation in reflex sympathetic dystrophy: B. J. van Hilten et al., N. Engl. J. Med. 343, 625 (2000).
Properties: Crystals from water, mp 206-208° (Keberle); 189-191°, (Uchimaru). LD50 in male mice, rats (mg/kg): 45, 78 i.v.; 103, 115 s.c.; 200, 145 orally (Tadokoro).
Melting point: mp 206-208° (Keberle); 189-191°, (Uchimaru)
Toxicity data: LD50 in male mice, rats (mg/kg): 45, 78 i.v.; 103, 115 s.c.; 200, 145 orally (Tadokoro)
 
Derivative Type: Hydrochloride
Molecular Formula: C10H13Cl2NO2
Molecular Weight: 250.12
Percent Composition: C 48.02%, H 5.24%, Cl 28.35%, N 5.60%, O 12.79%
Properties: mp 179-181°.
Melting point: mp 179-181°
 
Therap-Cat: Muscle relaxant (skeletal).
Keywords: Muscle Relaxant (Skeletal).