Home > Name List By 4 > 4-amino-N-(1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide

CAS No 112727-80-7 , 4-amino-N-(1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide

  • Name: 4-amino-N-(1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide
  • Synonyms: LS-187513; Renzapridum;Renzapride; Renzaprida; 112727-80-7; Renzapride [INN]; Renzapride (INN); AC1MJ6DN;4-amino-N-(1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide; MK-0646; LS-186857;
  • CAS Registry Number:
  • Flash Point: 237.6°C
  • Boiling Point: 469.2°Cat760mmHg
  • Density: 1.3g/cm3
  • Refractive index: 1.614
  • Flash Point: 237.6°C
  • Molecular Weight: 323.81778
  • InchiKey: GZSKEXSLDPEFPT-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H22ClN3O2/c1-22-15-8-13(18)12(17)7-11(15)16(21)19-14-4-6-20-
    5-2-3-10(14)9-20/h7-8,10,14H,2-6,9,18H2,1H3,(H,19,21)
  • Molecular Formula: C16H22ClN3O2
  • Molecular Structure:CAS No:112727-80-7 4-amino-N-(1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide

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References of 4-amino-N-(1-azabicyclo[3.3.1]nonan-4-yl)-5-chloro-2-methoxybenzamide
Title: Renzapride
CAS Registry Number: 112727-80-7
CAS Name: rel-4-Amino-N-(1R,4S,5R)-1-azabicyclo[3.3.1]non-4-yl-5-chloro-2-methoxybenzamide
Synonyms: (±)-endo-4-amino-5-chloro-2-methoxy-N-(1-azabicyclo[3.3.1]non-4-yl)benzamide
Manufacturers' Codes: ATL-1251; BRL-24924
Molecular Formula: C16H22ClN3O2
Molecular Weight: 323.82
Percent Composition: C 59.35%, H 6.85%, Cl 10.95%, N 12.98%, O 9.88%
Literature References: Serotonin receptor 5-HT4 agonist/5-HT3 antagonist. Prepn: F. D. King, EP 94742; idem, US 4612319 (1983, 1986 both to Beecham); idem et al., J. Med. Chem. 36, 683 (1993). 5-HT4 receptor selectivity as quaternary salt: G. S. Baxter et al., Bioorg. Med. Chem. Lett. 3, 633 (1993). Clinical pharmacology: D. H. Staniforth, M. Pennick, Eur. J. Clin. Pharmacol. 38, 161 (1990). Clinical evaluation in irritable bowel syndrome: M. Camilleri et al., Clin. Gastroenterol. Hepatol. 2, 895 (2004). Review: P. Norman, Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs 2, 355-368 (2000).
Properties: mp >260°.
Melting point: mp >260°
Therap-Cat: Gastroprokinetic. In treatment of irritable bowel syndrome.
Keywords: Gastroprokinetic.