Home > Name List By 1 > 1-[6-amino-2-[hydroxy(4-phenylbutyl)phosphoryl]oxyhexanoyl]pyrrolidine- 2-carboxylic acid

CAS No 111223-26-8 , 1-[6-amino-2-[hydroxy(4-phenylbutyl)phosphoryl]oxyhexanoyl]pyrrolidine-
2-carboxylic acid

  • Name: 1-[6-amino-2-[hydroxy(4-phenylbutyl)phosphoryl]oxyhexanoyl]pyrrolidine-
    2-carboxylic acid
  • Synonyms: Ceronaprilum [INN-Latin]; 111223-26-8; CERONAPRIL;1-[6-amino-2-[hydroxy(4-phenylbutyl)phosphoryl]oxyhexanoyl]pyrrolidine-
    2-carboxylic acid; SQ 29852;Ceranapril; BRN 3635091;
  • CAS Registry Number:
  • Flash Point: 366.7°C
  • Boiling Point: 682.8°C at 760 mmHg
  • Density: 1.265g/cm3
  • Refractive index: 1.559
  • Flash Point: 366.7°C
  • Molecular Weight: 440.470282
  • InchiKey: IFYLTXNCFVRALQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C21H33N2O6P/c22-14-6-4-13-19(20(24)23-15-8-12-18(23)21(25)26)
    29-30(27,28)16-7-5-11-17-9-2-1-3-10-17/h1-3,9-10,18-19H,4-8,11-16,22H2,
    (H,25,26)(H,27,28)
  • Molecular Formula: C21H33N2O6P
  • Molecular Structure:CAS No:111223-26-8 1-[6-amino-2-[hydroxy(4-phenylbutyl)phosphoryl]oxyhexanoyl]pyrrolidine-<br />2-carboxylic acid

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111223-26-8 Ceronapril

  • Ceronapril, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
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111223-26-8 CERONAPRIL

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
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    (N)Nanjing 210009,China null,nullChina
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References of 1-[6-amino-2-[hydroxy(4-phenylbutyl)phosphoryl]oxyhexanoyl]pyrrolidine-
2-carboxylic acid
Title: Ceronapril
CAS Registry Number: 111223-26-8
CAS Name: 1-[(2S)-6-Amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-1-oxohexyl]-L-proline
Synonyms: 1-[(2S)-6-amino-2-hydroxyhexanoyl]-L-proline, hydrogen (4-phenylbutyl)phosphonate (ester); ceranapril
Manufacturers' Codes: SQ-29852
Molecular Formula: C21H33N2O6P
Molecular Weight: 440.47
Percent Composition: C 57.26%, H 7.55%, N 6.36%, O 21.79%, P 7.03%
Literature References: Hydroxylphosphonate angiotensin converting enzyme (ACE) inhibitor. Prepn: D. S. Karanewsky, E. W. Petrillo, Jr., EP 97534; eidem, US 4452790 (both 1984 to Squibb); eidem et al., J. Med. Chem. 31, 204 (1988). HPLC determn in body fluids: H. Kadin et al., J. Chromatogr. 487, 135 (1989). Pharmacology: J. M. DeForrest et al., J. Cardiovasc. Pharmacol. 16, 121 (1990). Radioimmunoassay and pharmacokinetics: J. Tu et al., Ther. Drug Monit. 14, 209 (1992). Clinical evaluation in hypertension: J. Sasaki et al., Int. J. Clin. Pharmacol. Ther. Toxicol. 31, 83 (1993).
Properties: Prepd as the monohydrate. Crystals from water, mp 190-195° (dec). [a]D -47.5° (c = 1 in methanol).
Melting point: mp 190-195° (dec)
Optical Rotation: [a]D -47.5° (c = 1 in methanol)
Therap-Cat: Antihypertensive.
Keywords: ACE-Inhibitor; Antihypertensive; N-Carboxyalkyl (peptide/lactam) Derivatives.