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CAS No 111025-46-8 , 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,
4-dione Search by region : China

  • Name: 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,
    4-dione
  • Synonyms: Pioglitazonum; 111025-46-8; Actost;Actos; Glustin; Pioglitazonum [INN-Latin]; Zactos; Pioglitazona; Pioglitazona [INN-Spanish];5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,
    4-dione;
  • CAS Registry Number:
  • Melting Point: 183-184 C
  • Density: 1.26 g/cm3
  • Water Solubility: Soluble in DMF; slightly soluble in ethanol; practically insoluble in water
  • Safety Statements: R20/21/22
  • Hazard Symbols: F,C
  • Molecular Weight: 356.4387
  • InchiKey: HYAFETHFCAUJAY-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)
    11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)
  • Risk Statements: S36/37
  • Molecular Formula: C19H20N2O3S
  • Molecular Structure:CAS No:111025-46-8 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,<br />4-dione

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References of 5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,
4-dione
Title: Pioglitazone
CAS Registry Number: 111025-46-8
CAS Name: 5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione
Synonyms: (±)-5-[p-[2-(ethyl-2-pyridyl)ethoxy]benzyl]-2,4-thiazolidinedione
Manufacturers' Codes: AD-4833
Molecular Formula: C19H20N2O3S
Molecular Weight: 356.44
Percent Composition: C 64.02%, H 5.66%, N 7.86%, O 13.47%, S 9.00%
Literature References: Insulin sensitizer. Prepn: K. Meguro, T. Fujita, EP 193256; eidem, US 4687777 (1986, 1987 both to Takeda); T. Sohda et al., Arzneim.-Forsch. 40, 37 (1990). Pharmacology: H. Ikeda et al., ibid. 156. HPLC determn in serum: W. Z. Zhong, D. B. Lakings, J. Chromatogr. 490, 377 (1989). Mechanism of action: C. Hofmann et al., Endocrinology 129, 1915 (1991); M. Kobayashi et al., Diabetes 41, 476 (1992). Effect on adipocyte differentiation: T. Sandouk et al., Am. J. Physiol. 264, C1600 (1993). Clinical evaluation in noninsulin-dependent diabetes: R. Kawamori et al., Diabetes Res. Clin. Pract. 41, 35 (1998).
Properties: Colorless needles from DMF + water, mp 183-184°.
Melting point: mp 183-184°
 
Derivative Type: Hydrochloride
CAS Registry Number: 112529-15-4
Manufacturers' Codes: U-72107A
Trademarks: Actos (Takeda)
Molecular Formula: C19H20N2O3S.HCl
Molecular Weight: 392.90
Percent Composition: C 58.08%, H 5.39%, N 7.13%, O 12.22%, S 8.16%, Cl 9.02%
Properties: Colorless prisms from ethanol, mp 193-194°. Sol in DMF; slightly sol in ethanol; very slightly sol in acetone, acetonitrile. Practically insol in water; insol in ether.
Melting point: mp 193-194°
 
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Thiazolidinediones; Insulin Sensitizer.