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CAS No 106602-62-4 , Amylin

  • Name: Amylin
  • Synonyms: Insulinoma amyloid polypeptide;Diabetes-associatedpeptide; Insulinoma amyloid peptide;Amylin; Isletamyloid polypeptide;
  • CAS Registry Number:
  • Molecular Weight: 0
  • InChI: InChI=1S/C165H261N51O55S2/c1-22-75(12)124(159(266)200-95(47-71(4)5)140(247)203-108(64-219)153(260)206-110(66-221)154(261)216-129(84(21)226)163(270)202-105(58-119(174)234)147(254)209-122(73(8)9)157(264)181-61-121(236)187-106(62-217)150(257)198-103(56-117(172)232)148(255)215-128(83(20)225)162(269)190-93(130(175)237)49-87-38-40-89(227)41-39-87)211-132(239)76(13)183-120(235)60-180-136(243)97(50-85-32-25-23-26-33-85)194-144(251)101(54-115(170)230)196-145(252)102(55-116(171)231)197-151(258)107(63-218)205-152(259)109(65-220)204-142(249)99(52-88-59-178-69-182-88)201-158(265)123(74(10)11)210-146(253)96(48-72(6)7)193-141(248)98(51-86-34-27-24-28-35-86)195-143(250)100(53-114(169)229)191-131(238)77(14)184-139(246)94(46-70(2)3)192-137(244)91(37-31-45-179-165(176)177)188-138(245)92(42-43-113(168)228)189-161(268)126(81(18)223)212-133(240)78(15)185-155(262)111-67-272-273-68-112(207-135(242)90(167)36-29-30-44-166)156(263)199-104(57-118(173)233)149(256)214-125(80(17)222)160(267)186-79(16)134(241)213-127(82(19)224)164(271)208-111/h23-28,32-35,38-41,59,69-84,90-112,122-129,217-227H,22,29-31,36-37,42-58,60-68,166-167H2,1-21H3,(H2,168,228)(H2,169,229)(H2,170,230)(H2,171,231)(H2,172,232)(H2,173,233)(H2,174,234)(H2,175,237)(H,178,182)(H,180,243)(H,181,264)(H,183,235)(H,184,246)(H,185,262)(H,186,267)(H,187,236)(H,188,245)(H,189,268)(H,190,269)(H,191,238)(H,192,244)(H,193,248)(H,194,251)(H,195,250)(H,196,252)(H,197,258)(H,198,257)(H,199,263)(H,200,266)(H,201,265)(H,202,270)(H,203,247)(H,204,249)(H,205,259)(H,206,260)(H,207,242)(H,208,271)(H,209,254)(H,210,253)(H,211,239)(H,212,240)(H,213,241)(H,214,256)(H,215,255)(H,216,261)(H4,176,177,179)/t75-,76-,77-,78-,79-,80+,81+,82+,83+,84+,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,122-,123-,124-,125-,126-,127-,128-,129-/m0/s1
  • Molecular Formula: C165H261N51O55S2
  • Molecular Structure:CAS No:106602-62-4 Amylin

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106602-62-4 Amylin

  • Amylin, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
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References of Amylin
Title: Amylin
CAS Registry Number: 106602-62-4
Synonyms: Diabetes-associated peptide; insulinoma amyloid peptide; islet amyloid polypeptide; IAPP
Literature References: Peptide hormone co-secreted with insulin by pancreatic beta cells in response to a meal or other nutrient stimuli. Affects carbohydrate absorption and disposition; modulates the effects of insulin. Major component of pancreatic amyloid deposits characteristic of noninsulin-dependent diabetes and thought to be involved in insulin resistance. Amylin deficiency occurs in insulin-dependent diabetes and may contribute to excessive insulin sensitivity and a heightened tendency to hypoglycemia. Structurally homologous with calcitonin gene related peptide, sharing certain bioactivities such as vasodilation, osteoclast inhibition, and appetite suppression. Isoln from human insulinoma amyloid: P. Westermark et al., Biochem. Biophys. Res. Commun. 140, 827 (1986); from diabetic islet amyloid: idem et al., Am. J. Pathol. 127, 414 (1987); G. J. S. Cooper et al., Proc. Natl. Acad. Sci. USA 84, 8628 (1987). Review of bioactivities: B. J. Edwards, J. E. Morley, Life Sci. 51, 1899-1912 (1992); T. J. Rink et al., Trends Pharmacol. Sci. 14, 113-118 (1993). Review of role in insulin resistance: B. Leighton, G. J. S. Cooper, Trends Biochem. Sci. 15, 295-299 (1990); in carbohydrate metabolism: A. Young et al., Biochem. Soc. Trans. 23, 325 (1995). Effects on appetite regulation and memory: J. E. Morley et al., Can. J. Physiol. Pharmacol. 73, 1042-1046 (1995). Review of role in age-related disease and therapeutic potential: G. J. S. Cooper, C. A. Tse, Drugs Aging 9, 202-212 (1996).
 
Derivative Type: Human amylin
CAS Registry Number: 122384-88-7
Synonyms: Amlintide
Manufacturers' Codes: AC-001
Molecular Formula: C165H261N51O55S2
Molecular Weight: 3903.28
Percent Composition: C 50.77%, H 6.74%, N 18.30%, O 22.54%, S 1.64%
Properties: Composed of 37 amino acid residues; mol wt 3903.35.
 
Therap-Cat: In treatment of insulin-dependent diabetes.
Keywords: Antidiabetic; Hormones/Analogs.