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CAS No 106308-44-5 , 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide Search by region : China

  • Name: 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide
  • Synonyms: Inovelon; Cgp 33101; Rufinamide; Xilep; 106308-44-5; Banzel; RUF-331; S1256_Selleck; CGP-33101;1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide;
  • CAS Registry Number:
  • Density: 1.52 g/cm3
  • Refractive index: 1.634
  • Molecular Weight: 238.193526
  • InchiKey: POGQSBRIGCQNEG-UHFFFAOYSA-N
  • InChI: InChI=1S/C10H8F2N4O/c11-7-2-1-3-8(12)6(7)4-16-5-9(10(13)17)14-15-16/h1-
    3,5H,4H2,(H2,13,17)
  • Molecular Formula: C10H8F2N4O
  • Molecular Structure:CAS No:106308-44-5 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide

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References of 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide
Title: Rufinamide
CAS Registry Number: 106308-44-5
CAS Name: 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
Synonyms: 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide
Manufacturers' Codes: CGP-33101
Trademarks: Inovelon (Eisai)
Molecular Formula: C10H8F2N4O
Molecular Weight: 238.19
Percent Composition: C 50.42%, H 3.39%, F 15.95%, N 23.52%, O 6.72%
Literature References: Antiepileptic triazole derivative which decreases firing by neurons at sodium channels. Prepn: R. Meier, EP 199262; eidem, US 4789680 (1986, 1988 both to Ciba-Geigy). HPLC determn in human plasma: L. A. Brunner, M. L. Powell, Biomed. Chromatogr. 6, 278 (1992). Clinical pharmacokinetics: W. K. Cheung et al., Pharm. Res. 12, 1878 (1995); and tolerability: J.-M. Cardot et al., Biopharm. Drug Dispos. 19, 259 (1998). Clinical study in epilepsy: S. Palhagen et al., Epilepsy Res. 43, 115 (2001). Review of clinical experience: K. K. Jain et al., Exp. Opin. Invest. Drugs 9, 829-840 (2000).
Properties: Crystals from ethanol, mp 237-240°. Moderate soly in 0.1N HCl.
Melting point: mp 237-240°
Therap-Cat: Anticonvulsant.
Keywords: Anticonvulsant.