Home > Name List By 1 > 1-Azoniabicyclo[2.2.2]octane,4-(aminocarbonyl)-1-[[(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetyl]...

CAS No 105239-91-6 , 1-Azoniabicyclo[2.2.2]octane,4-(aminocarbonyl)-1-[[(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,inner salt

  • Name: 1-Azoniabicyclo[2.2.2]octane,4-(aminocarbonyl)-1-[[(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,inner salt
  • Synonyms: Cefclidine; E 1040 (antibiotic);E 1040; 1,2,4-Thiadiazole,1-azoniabicyclo[2.2.2]octane deriv.;1-Azoniabicyclo[2.2.2]octane,4-(aminocarbonyl)-1-[[(6R,7R)-7-[[(2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,inner salt (9CI); Antibiotic E 1040; Cefclidin;1-Azoniabicyclo[2.2.2]octane,4-(aminocarbonyl)-1-[[(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,inner salt; 1-Azoniabicyclo[2.2.2]octane,4-(aminocarbonyl)-1-[[7-[[(5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,inner salt, [6R-[6a,7b(Z)]]-;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: g/cm3
  • Flash Point: °C
  • Molecular Weight: 0
  • InChI: InChI=1/C21H26N8O6S2/c1-35-26-11(14-25-20(23)37-27-14)15(30)24-12-16(31)28-13(18(32)33)10(9-36-17(12)28)8-29-5-2-21(3-6-29,4-7-29)19(22)34/h12,17H,2-9H2,1H3,(H5-,22,23,24,25,27,30,32,33,34)/b26-11-/t12-,17-,21?,29?/m1/s1
  • Molecular Formula: C21H26 N8 O6 S2
  • Molecular Structure:CAS No:105239-91-6 1-Azoniabicyclo[2.2.2]octane,4-(aminocarbonyl)-1-[[(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,inner salt

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105239-91-6 Cefclidin

  • Cefclidin, Min 99%
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105239-91-6 Cefclidin

  • Cefclidin, 99%
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References of 1-Azoniabicyclo[2.2.2]octane,4-(aminocarbonyl)-1-[[(6R,7R)-7-[[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-,inner salt
Title: Cefclidin
CAS Registry Number: 105239-91-6
CAS Name: 4-(Aminocarbonyl)-1-[[(6R,7R)-7-[[(2Z)-(5-amino-1,2,4-thiadiazol-3-yl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-azoniabicyclo[2.2.2]octane inner salt
Synonyms: (6R,7R)-3-[(4-carbamoyl-1-quinuclidinio)methyl]-7-[2-(5-amino-1,2,4-thiadiazol-3-yl)-(Z)-2-methoxyiminoacetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-1-ene-2-carboxylate; (+)-1-[[(6R,7R)-7-[2-(5-amino-1,2,4-thiadiazol-3-yl)glyoxylamido]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-4-carbamoylquinuclidinium hydroxide inner salt 72-(Z)-(O-methyloxime); 7b-[(Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-methoxyiminoacetamido]-3-(4-carbamoyl-1-quinuclidinio)methyl-3-cephem-4-carboxylate
Manufacturers' Codes: E-1040
Molecular Formula: C21H26N8O6S2
Molecular Weight: 550.61
Percent Composition: C 45.81%, H 4.76%, N 20.35%, O 17.43%, S 11.65%
Literature References: Broad spectrum fourth generation cephalosporin antibiotic. Prepn: H. Yamauchi et al., EP 188255; eidem, US 4748171 (1986, 1988 both to Eisai). Structure activity study: I. Sugiyama et al., J. Antibiot. 45, 103 (1992). Comparative in vitro antibacterial spectrum and b-lactamase resistance: N.-A. Watanabe et al., Antimicrob. Agents Chemother. 32, 693 (1988). In vivo antipseudomonal activity: T. Toyosawa et al., Chemotherapy (Tokyo) 42, 1242 (1994). Clinical pharmacokinetics: M. Nakashima et al., J. Clin. Pharmacol. 29, 144 (1989). Toxicity study: K. Ogura et al., Chemotherapy (Tokyo) 40, Suppl. 4, 95 (1992).
Properties: LD50 in male, female mice, rats (mg/kg): >10000, >10000, 2236, 2147 i.v.; >10000 both species orally; >10000 both species s.c.; >5000 both species i.m. (Ogura).
Toxicity data: LD50 in male, female mice, rats (mg/kg): >10000, >10000, 2236, 2147 i.v.; >10000 both species orally; >10000 both species s.c.; >5000 both species i.m. (Ogura)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Cephalosporins.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.