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CAS No 104227-87-4 , [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate

  • Name: [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate
  • Synonyms: Anti-Farnesyl Rabbit pAb; Oravir; BRL 42810;[2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate; Famciclovirum;Famvir; 104227-87-4; BRL-42810; Famciclovirum [INN-Latin];
  • CAS Registry Number:
  • Density: 1.4g/cm3
  • Refractive index: 1.628
  • Safety Statements: 36/37/39-45-53
  • Hazard Symbols: T: Toxic;
  • Molecular Weight: 321.33176
  • InchiKey: GGXKWVWZWMLJEH-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H19N5O4/c1-9(20)22-6-11(7-23-10(2)21)3-4-19-8-17-12-5-16-14
    (15)18-13(12)19/h5,8,11H,3-4,6-7H2,1-2H3,(H2,15,16,18)
  • Risk Statements: 20/21/22-45-61
  • Molecular Formula: C14H19N5O4
  • Molecular Structure:CAS No:104227-87-4 [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate

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References of [2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate
Title: Famciclovir
CAS Registry Number: 104227-87-4
CAS Name: 2-[2-(2-Amino-9H-purin-9-yl)ethyl]-1,3-propanediol diacetate (ester)
Synonyms: 9-[4-acetoxy-3-(acetoxymethyl)but-1-yl]-2-aminopurine; FCV
Manufacturers' Codes: BRL-42810
Trademarks: Oravir (SKB); Famvir (SKB)
Molecular Formula: C14H19N5O4
Molecular Weight: 321.33
Percent Composition: C 52.33%, H 5.96%, N 21.79%, O 19.92%
Literature References: Prodrug of penciclovir, q.v. Prepn: M. R. Harnden, R. L. Jarvest, AU 85 47560; eidem, US 5246937 (1986, 1993 both to Beecham); M. R. Harnden et al., J. Med. Chem. 32, 1738 (1989). HPLC determn in plasma and urine: J. R. McMeekin et al., Anal. Proc. 29, 178 (1992). Review of metabolism and mode of action: R. A. Vere Hodge, Antiviral Chem. Chemother. 4, 67-84 (1993). Series of articles on pharmacology and pharmacokinetics: ibid. Suppl. 1, 37-68 (1993). Review of clinical efficacy in herpes zoster and genital herpes: R. Circelli et al., Antiviral Res. 29, 141-151 (1996).
Properties: White shiny plates from ethyl acetate-hexane, mp 102-104°. uv max (methanol): 222, 244, 309 nm (e 27500, 4890, 7160). Sol in water (25°): >25% w/v initially; rapidly ppts as sparingly sol monohydrate (2-3% w/v). Freely sol in acetone, methanol; sparingly sol in ethanol, isopropanol.
Melting point: mp 102-104°
Absorption maximum: uv max (methanol): 222, 244, 309 nm (e 27500, 4890, 7160)
Therap-Cat: Antiviral.
Keywords: Antiviral; Purines/Pyrimidinones.