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CAS No 103775-75-3 , Miboplatin

  • Name: Miboplatin
  • Synonyms: Lobaplatin; (-)-cis-((R)-2-(Aminomethyl)pyrrolidine)(1,1-cyclobutanedicarboxylato)platinum;Miboplatin;
  • CAS Registry Number:
  • Flash Point: 189.6 ºC
  • Boiling Point: 366.4 ºC
  • Density: g/cm3
  • Flash Point: 189.6 ºC
  • Molecular Weight: 437.35
  • InChI: InChI=1/C6H8O4.C5H12N2.Pt/c7-4(8)6(5(9)10)2-1-3-6;6-4-5-2-1-3-7-5;/h1-3H2,(H,7,8)(H,9,10);5,7H,1-4,6H2;/q;;+2/p-2/t;5-;/m.1./s1
  • Molecular Formula: C11H18N2O4Pt
  • Molecular Structure:CAS No:103775-75-3 Miboplatin

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103775-75-3 LOBAPLATIN

  • China HANGZHOU ONICON CHEMICAL CO.,LTD [Manufacturer]
  • Tel: +86-571-85054016/ +86-571-85104679
  • Fax: +86-571-85054082
  • Address: HANGZHOU ONICON CHEMICAL CO.,LTD
    303-306 Hangzhou yiyao Building,
    No.439 Zhongshan North Rd.
    Hangzhou China
    Phone : +86-571-85054016
    Fax: +86-571-85054082
    E-Mail1: cjw9999@163.com null,nullChina
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103775-75-3 Platinum,[1,1-cyclobutanedi(carboxylato-kO)(2-)][(1R,2R)-2-pyrrolidinemethanamine-kN1,kN2]-, (SP-4-3)-

  • China Hangzhou R&S Pharmchem Co., Ltd [Manufacturers]
  • Tel: +86-571-85774292
  • Fax: +86-571-85774298
  • Address: 1403 B. C. No.308 North Zhongshan Road, Hangzhou City, Zhejiang Province, P. R. China Hangzhou,ZhejiangChina
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103775-75-3 MIBOPLATIN

  • China Nanjing Chemlin Chemical Industry Co.,Ltd. [Manufacturer]
  • Tel: +86 25 8369-7070/ +86 138 51816776 (Mobile)
  • Fax: +86 25 8345-3275
  • Address: Rm.902 Longyin Plaza,
    No. 217 Zhongshan Rd.
    (N)Nanjing 210009,China null,nullChina
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References of Miboplatin
Title: Miboplatin
CAS Registry Number: 103775-75-3
CAS Name: (SP-4-3)-[1,1-Cyclobutanedi(carboxylato-kO)(2-)][(1R,2R)-2-pyrrolidinemethanamine-kN1,kN2]platinum
Synonyms: (-)-cis-[(R)-2-(aminomethyl)pyrrolidine](1,1-cyclobutanedicarboxylato)platinum; (-)-(R)-1,1-cyclobutanedicarboxylato(2-aminomethylpyrrolidine)platinum(II)
Molecular Formula: C11H18N2O4Pt
Molecular Weight: 437.36
Percent Composition: C 30.21%, H 4.15%, N 6.41%, O 14.63%, Pt 44.60%
Literature References: Cytotoxic platinum complex. Prepn: M. Honda et al., EP 176005; eidem, US 4822892 (1986, 1989 both to Chugai); K. Morikawa et al., J. Pharm. Sci. 80, 837 (1991). Comparative antitumor and nephrotoxic activities of isomers: T. Matumoto et al., Br. J. Cancer 64, 41 (1991). Mechanism of action studies: M. Itoh et al., Chem. Pharm. Bull. 37, 2825 (1989); M. Akaboshi et al., Jpn. J. Cancer Res. 85, 106 (1994). Clinical evaluation: K. Tamura et al., Cancer 66, 2059 (1990). Acute toxicity: M. Suzuki et al., Yakuri to Chiryo 20, S743 (1992), C.A. 117, 124096 (1992).
 
Derivative Type: Monohydrate
Manufacturers' Codes: DWA-2114R
Trademarks: Neoplat (Chugai)
Properties: Colorless crystals from water, mp 248-254°. [a]D20 -40.1° (c = 0.4 in water). LD50 in male, female mice, rats (mg/kg): 150, 155, 107, 135 i.v. (Suzuki).
Melting point: mp 248-254°
Optical Rotation: [a]D20 -40.1° (c = 0.4 in water)
Toxicity data: LD50 in male, female mice, rats (mg/kg): 150, 155, 107, 135 i.v. (Suzuki)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Platinum Complexes.
 
 
Status: This monograph has been retired and is no longer subject to revision or update.