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CAS No 103177-37-3 , Pranlukast Search by region : China

  • Name: Pranlukast
  • Synonyms: o-(p-hydroxybenzoyl)-benzoicaci; 2-(4-hydroxybenzoyI)benzoic acid;Pranlukast; phthaleinacid; PLST; AKOS B028764;4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran;N-(4-oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl)-4-(4-phenylbutoxy)benzamide; 2-(4-HYDROXYBENZOYL)BENZOIC ACID; 2-(4-hydroxybenzoyl)-benzoicaci; N-(4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide; o-(p-hydroxybenzoyl)benzoicacid; 2-(P-HYDROXYBENZOYL)BENZOIC AC ID;
  • CAS Registry Number:
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.374g/cm3
  • Refractive index: 1.68
  • Safety Statements: S16;S26;S36/37/39;S45;
  • Hazard Symbols: F,C
  • Flash Point: °C
  • EINECS: 201-616-4
  • Molecular Weight: 481.50
  • InChI: InChI=1/C27H23N5O4/c33-23-17-25(26-29-31-32-30-26)36-24-16-20(11-14-22(23)24)28-27(34)19-9-12-21(13-10-19)35-15-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-14,16-17H,4-5,8,15H2,(H,28,34)(H,29,30,31,32)
  • Risk Statements: 11-34
  • Molecular Formula: C27H23N5O4
  • Molecular Structure:CAS No:103177-37-3 Pranlukast

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References of Pranlukast
Title: Pranlukast
CAS Registry Number: 103177-37-3
CAS Name: N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide
Synonyms: 8-[4-(4-phenylbutoxy)benzamido]-2-(tetrazol-5-yl)-4H-1-benzopyran-4-one; 8-[p-(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran
Manufacturers' Codes: ONO-1078; ONO-RS-411
Trademarks: Onon (Ono)
Molecular Formula: C27H23N5O4
Molecular Weight: 481.50
Percent Composition: C 67.35%, H 4.81%, N 14.54%, O 13.29%
Literature References: Leukotriene antagonist. Prepn: M. Toda et al., EP 173516; eidem, US 4780469 (1986, 1988 both to Ono); H. Nakai et al., J. Med. Chem. 31, 84 (1988). Pharmacology: T. Obata et al., Adv. Prostaglandin Thromboxane Leukotriene Res. 15, 229 (1985); idem et al., ibid. 17, 540 (1987). Clinical evaluations in asthma: Y. Taniguchi et al., J. Allergy Clin. Immunol. 92, 507 (1993); H. Yamamoto et al. Am. J. Respir. Crit. Care Med. 150, 254 (1994).
Properties: Occurs as the hemihydrate. Crystals, mp 244-245°. LD50 in male mice (mg/kg): >1000 i.v. (Toda).
Melting point: mp 244-245°
Toxicity data: LD50 in male mice (mg/kg): >1000 i.v. (Toda)
Therap-Cat: Antiasthmatic.
Keywords: Antiasthmatic (Nonbronchodilator); Leukotriene Antagonist.