Home > Name List By m > Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-,(6R,23S)-

CAS No 102130-84-7 , Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-,(6R,23S)-

  • Name: Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-,(6R,23S)-
  • Synonyms: MilbemycinB, 5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-hydroxy-,[6R,23S,25S(E)]- (9CI); Antibiotic LL-F 28249a; Nemadectin; F 28249a; LL-F 28249a;Spiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,2'-[2H]pyran],milbemycin B deriv.; Megatop; Nemadectina; L 669437;Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-,(6R,23S)-; CL 287088; Antibiotic S 541A;
  • CAS Registry Number:
  • Transport: 2588
  • Flash Point: 241.9°C
  • Boiling Point: 786°Cat760mmHg
  • Density: 1.19g/cm3
  • Safety Statements: RIDADR 2588HazardClass 6.1(b)PackingGroup III
  • Flash Point: 241.9°C
  • Molecular Weight: 0
  • InChI: InChI=1/C36H52O8/c1-20(2)13-24(6)32-25(7)30(37)18-35(44-32)17-28-16-27(43-35)12-11-22(4)14-21(3)9-8-10-26-19-41-33-31(38)23(5)15-29(34(39)42-28)36(26,33)40/h8-11,13,15,20-21,25,27-33,37-38,40H,12,14,16-19H2,1-7H3/b9-8+,22-11+,24-13+,26-10+/t21-,25-,27+,28-,29-,30-,31+,32+,33+,35-,36+/m0/s1
  • Molecular Formula: C36H52 O8
  • Molecular Structure:CAS No:102130-84-7 Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-,(6R,23S)-

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102130-84-7 NEMADECTIN

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
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    Germany null,nullGermany
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References of Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-hydroxy-,(6R,23S)-
Title: Nemadectin
CAS Registry Number: 102130-84-7
CAS Name: [6R,23S,25S(E)]-5-O-Demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-hydroxymilbemycin B
Synonyms: antibiotic S-541A
Manufacturers' Codes: LL-F-28249a; F-28249a; CL-287088
Molecular Formula: C36H52O8
Molecular Weight: 612.79
Percent Composition: C 70.56%, H 8.55%, O 20.89%
Literature References: Macrocyclic antibiotic produced by Streptomyces cyaneogriseus ssp. noncyanogenus and Streptomyces thermoachaensis. Structurally related to the milbemycins and the avermectins, q.q.v. Isoln: I. B. Wood et al., EP 170006; I. B. Wood, J. A. Pankavich, US 4869901 (1986, 1989 both to Am. Cyanamid). Chemical and structural characterization: G. T. Carter et al., Chem. Commun. 1987, 402; G. T. Carter et al., J. Antibiot. 41, 519 (1988). NMR spectroscopy: S. Rajan, G. W. Stockton, Magn. Reson. Chem. 27, 437 (1989). Antiparasitic activity in horses: E. T. Lyons et al., Am. J. Vet. Res. 50, 970 (1989); in dogs: M. E. Doscher et al., Vet. Parasitol. 34, 255 (1989); in sheep: J. A. Pankavich et al, Vet. Rec. 130, 241, (1992).
Properties: White fluffy solid from tert-butanol. [a]D26 +133° (c = 0.3 in acetone). uv max (methanol): 244 nm, (log e 4.47). Readily sol in common organic solvents. Practically insol in water.
Optical Rotation: [a]D26 +133° (c = 0.3 in acetone)
Absorption maximum: uv max (methanol): 244 nm
Therap-Cat-Vet: Antiparasitic.