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CAS No 101828-21-1 , 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine Search by region : Japan

  • Name: 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
  • Synonyms: 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine; Mentax-TC;Butenafina; Mentax; Butenafina [INN-Spanish]; Butenafine HCL; Butenafine [INN]; Butenafinum; Butenafinum [INN-Latin];
  • CAS Registry Number:
  • Flash Point: 187.7°C
  • Boiling Point: 426.1°Cat760mmHg
  • Density: 1.032g/cm3
  • Flash Point: 187.7°C
  • Molecular Weight: 317.46718
  • InchiKey: ABJKWBDEJIDSJZ-UHFFFAOYSA-N
  • InChI: InChI=1S/C23H27N/c1-23(2,
    3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,
    16-17H2,1-4H3
  • Molecular Formula: C23H27N
  • Molecular Structure:CAS No:101828-21-1 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine

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101828-21-1 Butenafine

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References of 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
Title: Butenafine
CAS Registry Number: 101828-21-1
CAS Name: N-[[4-(1,1-Dimethylethyl)phenyl]methyl]-N-methyl-1-naphthalenemethanamine
Synonyms: N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine
Molecular Formula: C23H27N
Molecular Weight: 317.47
Percent Composition: C 87.01%, H 8.57%, N 4.41%
Literature References: Benzylamine antifungal; squalene epoxidase inhibitor. Prepn: T. Maeda et al., EP 164697; eidem, US 5021458 (1985, 1991 both to Kaken). Antifungal activity in vivo: T. Arika et al., Antimicrob. Agents Chemother. 34, 2250 (1990). Review of antifungal activity, mechanism of action, and clinical trials: R. Fukushiro et al., in Recent Progress in Antifungal Chemotherapy, H. Yamaguchi et al., Eds. (Dekker, New York, 1992) pp. 147-157. Clinical trial in treatment of athlete's foot: T. A. Syed et al., Clin. Drug Invest. 9, 393 (2000).
 
Derivative Type: Hydrochloride
CAS Registry Number: 101827-46-7
Manufacturers' Codes: KP-363
Trademarks: Mentax (Kaken)
Molecular Formula: C23H27N.HCl
Molecular Weight: 353.93
Percent Composition: C 78.05%, H 7.97%, N 3.96%, Cl 10.02%
Properties: Crystals from acetone + ethanol, mp 211-213°. Easily sol in methanol, ethanol, dichloromethane, chloroform. Slightly sol in water.
Melting point: mp 211-213°
 
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Allylamines.