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CAS No 101001-34-7 , 1H-Pyrrole-1-aceticacid, 2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-, ethyl ester

  • Name: 1H-Pyrrole-1-aceticacid, 2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-, ethyl ester
  • Synonyms: 1H-Pyrrole-1-aceticacid, 2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-, ethyl ester;Ethyl2-[4,5-bis(p-methoxyphenyl)-2-thiazolyl]pyrrole-1-acetate; KBT 3022;Pamicogrel; KB 3022;
  • CAS Registry Number:
  • Flash Point: 316.8°C
  • Boiling Point: 600.3°Cat760mmHg
  • Density: 1.22g/cm3
  • Refractive index: 1.612
  • Flash Point: 316.8°C
  • Molecular Weight: 448.5341
  • InChI: InChI=1/C25H24N2O4S/c1-4-31-22(28)16-27-15-5-6-21(27)25-26-23(17-7-11-19(29-2)12-8-17)24(32-25)18-9-13-20(30-3)14-10-18/h5-15H,4,16H2,1-3H3
  • Molecular Formula: C25H24 N2 O4 S
  • Molecular Structure:CAS No:101001-34-7 1H-Pyrrole-1-aceticacid, 2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-, ethyl ester

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101001-34-7 1H-Pyrrole-1-aceticacid, 2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-, ethyl ester

  • China Zhuhai hengmao [Manufacturers]
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  • Address: xiangzhou, zhuhai, guangdong, China Zhuhai,GuangdongChina
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References of 1H-Pyrrole-1-aceticacid, 2-[4,5-bis(4-methoxyphenyl)-2-thiazolyl]-, ethyl ester
Title: Pamicogrel
CAS Registry Number: 101001-34-7
CAS Name: 2-[4,5-Bis(4-methoxyphenyl)-2-thiazolyl]-1H-pyrrole-1-acetic acid ethyl ester
Synonyms: ethyl 2-[4,5-bis(p-methoxyphenyl)-2-thiazolyl]pyrrole-1-acetate
Manufacturers' Codes: KB-3022; KBT-3022
Molecular Formula: C25H24N2O4S
Molecular Weight: 448.53
Percent Composition: C 66.94%, H 5.39%, N 6.25%, O 14.27%, S 7.15%
Literature References: Cyclooxygenase inhibitor. Prepn: K. Yoshino et al., EP 159677; eidem, US 4659726 (1985, 1987 both to Kanebo). HPLC determn in plasma and urine: Y. Nakada et al., Chem. Pharm. Bull. 38, 1093 (1990). Pharmacokinetics: Y. Nakada et al., Yakuzaigaku 53, 210 (1993), C.A. 120, 315100 (1993). Activity as antithrombotic: K. Yokoto et al., Jpn. J. Pharmacol. 68, 201 (1995); as platelet aggregation inhibitor: K. Yokoto et al., J. Pharm. Pharmacol. 47, 768 (1995). Evaluation of cerebral protective effects: N. Yamamoto et al., Jpn. J. Pharmacol. 69, 421 (1995); eidem, Eur. J. Pharmacol. 297, 225 (1996).
Properties: Crystals from ligroin, mp 132.5-135.5°. LD50 orally in male mice: >3000 mg/kg (Yoshino).
Melting point: mp 132.5-135.5°
Toxicity data: LD50 orally in male mice: >3000 mg/kg (Yoshino)
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic.