Title: Nicotinyl Alcohol
CAS Registry Number: 100-55-0
CAS Name: 3-Pyridinemethanol
Synonyms: b-pyridylcarbinol; 3-hydroxymethylpyridine; nicotinic alcohol
Manufacturers' Codes: Nu-2121
Trademarks: Roniacol (Roche); Ronicol
Molecular Formula: C6H7NO
Molecular Weight: 109.13
Percent Composition: C 66.04%, H 6.47%, N 12.83%, O 14.66%
Literature References: Prepd by catalytic hydrogenation of 3-pyridinecarboxaldehyde: Panizzon,
Helv. Chim. Acta 24, supplemental issue in honor of Gadient Engi, p 26E (1941); by lithium aluminum hydride reduction of ethyl nicotinate: Rosenmund, Zymalkowski,
Ber. 85, 156 (1952); Cohen,
US 2520037 (1950); Mosher, Tessieri,
J. Am. Chem. Soc. 73, 4926 (1951); of methyl nicotinate: Bohlmann,
Ber. 86, 1423 (1953). From 3-cyanopyridine: Chase,
US 2615896 (1952 to Hoffmann-La Roche); from 3-aminomethylpyridine: Schl?pfer,
US 2547048 (1951 to Hoffmann-La Roche); from thionicotinic acid
S-methyl ester: Ruzicka, Prelog,
US 2509171 (1950 to Ciba).
Properties: Very hygroscopic liquid. bp28 154°; bp16 144-145°; bp12 114°; bp0.1 110°. Freely sol in water, ether. Sparingly sol in petr ether.
Boiling point: bp28 154°; bp16 144-145°; bp12 114°; bp0.1 110°
Derivative Type: d-Tartrate
CAS Registry Number: 6164-87-0
Trademarks: Roniacol Tartrate (Roche); Radecol; Niltuvin (EGYT)
Molecular Formula: C6H7NO.C4H6O6
Molecular Weight: 259.21
Percent Composition: C 46.34%, H 5.06%, N 5.40%, O 43.21%
Properties: Crystals, sour taste, mp 147-148°. Sol in ether, freely sol in water, alcohol.
Melting point: mp 147-148°
Use: Solubilizer for riboflavin:
US 2458430 (1949).
Therap-Cat: Vasodilator (peripheral).
Keywords: Vasodilator (Peripheral).
