| Post Date: | 10 Oct 2011 |
| Expiry Date: | 04 Oct 2012 |
| CAS No: | 88150-47-4 |
| Detailed Description: | Amlodipine Maleate (GMP)
CAS: 88150-47-4 Introduction: Amlodipine Maleate is a calcium channel blocking agent,and It is effective in the treatment of angina pectoris and hypertension. It inhibits the influx of extracellular calcium across the myocardial and vascular smooth muscle cell membranes. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload. Another possible mechanism is that amlodipine inhibits vascular smooth muscle carbonic anhydrase I activity with consecutive pH increase which may be involved in intracelluar calcium influx through calcium channels. Simcere's Amlodipine Maleate API: Simcere's API and preparations of Amlodipine Maleate are both successfully passed and received SFDA GMP certification. Its brand name is Ningliping. Some inspection data Specification CP Properties Almost white crystalline powder Melting Point 173~174℃(Decomposed) Loss on drying 0.2 % Residue on ignition 0.2% max Heavy metals 20 ppm max Assay 99.9 % Package 20 kg/drum Keyword: Amlodipine Maleate, Amlodipine, 88150-47-4，Norvasc |
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